Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system

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Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system. / Myren, Maja; Olesen, Jes; Gupta, Saurabh.

I: Vascular Pharmacology, Bind 55, Nr. 1-3, 2012, s. 50-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Myren, M, Olesen, J & Gupta, S 2012, 'Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system', Vascular Pharmacology, bind 55, nr. 1-3, s. 50-8. https://doi.org/10.1016/j.vph.2011.06.004

APA

Myren, M., Olesen, J., & Gupta, S. (2012). Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system. Vascular Pharmacology, 55(1-3), 50-8. https://doi.org/10.1016/j.vph.2011.06.004

Vancouver

Myren M, Olesen J, Gupta S. Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system. Vascular Pharmacology. 2012;55(1-3):50-8. https://doi.org/10.1016/j.vph.2011.06.004

Author

Myren, Maja ; Olesen, Jes ; Gupta, Saurabh. / Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system. I: Vascular Pharmacology. 2012 ; Bind 55, Nr. 1-3. s. 50-8.

Bibtex

@article{7e3421dc02e640b58c66163ce419c067,
title = "Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system",
abstract = "Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation of the cranial arteries may also play a role in increasing nociception. Prostaglandin I(2) (PGI(2)) is capable of inducing a headache in healthy volunteers, a response that is likely to be mediated by the prostaglandin I(2) receptor (IP). This study investigates the functional and molecular characteristics of the IP receptor in the rat craniovascular system. In the closed cranial window model, iloprost, an IP receptor agonist, dilated the rat middle meningeal artery (MMA) (E(max)=170%±16%; pED(50)=6.5±0.2) but not the rat cerebral artery (CA) in vivo. The specific antagonist of the IP receptor, CAY10441, significantly blocked the iloprost-induced response dose-dependently, with the highest dose attenuating iloprost (1µgkg(-1)) induced dilatations by 70% (p",
author = "Maja Myren and Jes Olesen and Saurabh Gupta",
note = "Copyright {\textcopyright} 2011 Elsevier Inc. All rights reserved.",
year = "2012",
doi = "10.1016/j.vph.2011.06.004",
language = "English",
volume = "55",
pages = "50--8",
journal = "Vascular Pharmacology",
issn = "1537-1891",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system

AU - Myren, Maja

AU - Olesen, Jes

AU - Gupta, Saurabh

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2012

Y1 - 2012

N2 - Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation of the cranial arteries may also play a role in increasing nociception. Prostaglandin I(2) (PGI(2)) is capable of inducing a headache in healthy volunteers, a response that is likely to be mediated by the prostaglandin I(2) receptor (IP). This study investigates the functional and molecular characteristics of the IP receptor in the rat craniovascular system. In the closed cranial window model, iloprost, an IP receptor agonist, dilated the rat middle meningeal artery (MMA) (E(max)=170%±16%; pED(50)=6.5±0.2) but not the rat cerebral artery (CA) in vivo. The specific antagonist of the IP receptor, CAY10441, significantly blocked the iloprost-induced response dose-dependently, with the highest dose attenuating iloprost (1µgkg(-1)) induced dilatations by 70% (p

AB - Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation of the cranial arteries may also play a role in increasing nociception. Prostaglandin I(2) (PGI(2)) is capable of inducing a headache in healthy volunteers, a response that is likely to be mediated by the prostaglandin I(2) receptor (IP). This study investigates the functional and molecular characteristics of the IP receptor in the rat craniovascular system. In the closed cranial window model, iloprost, an IP receptor agonist, dilated the rat middle meningeal artery (MMA) (E(max)=170%±16%; pED(50)=6.5±0.2) but not the rat cerebral artery (CA) in vivo. The specific antagonist of the IP receptor, CAY10441, significantly blocked the iloprost-induced response dose-dependently, with the highest dose attenuating iloprost (1µgkg(-1)) induced dilatations by 70% (p

U2 - 10.1016/j.vph.2011.06.004

DO - 10.1016/j.vph.2011.06.004

M3 - Journal article

C2 - 21749934

VL - 55

SP - 50

EP - 58

JO - Vascular Pharmacology

JF - Vascular Pharmacology

SN - 1537-1891

IS - 1-3

ER -

ID: 40186614