pH gradient reversal fuels cancer progression
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
pH gradient reversal fuels cancer progression. / Zheng, Tianyu; Jäättelä, Marja; Liu, Bin.
I: International Journal of Biochemistry and Cell Biology, Bind 125, 105796, 2020.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - pH gradient reversal fuels cancer progression
AU - Zheng, Tianyu
AU - Jäättelä, Marja
AU - Liu, Bin
PY - 2020
Y1 - 2020
N2 - pH gradient reversal refers to intracellular alkalization and extracellular acidification commonly seen in malignant tumors. To meet their high anabolic demand, cancer cells rewire their glucose metabolism from oxidative phosphorylation to lactate fermentation, which results in the excessive generation of protons. To avoid lethal cytosolic acidification, lactate-fermenting cancer cells activate multiple acid removal pathways leading to the acidification of the extracellular space. This acidification is often further intensified by the defective capacity of the disorganized tumor vasculature to dilute protons away from the cancer tissue. The cancer-specific proton equilibrium with highly alkaline cytosol and acidic extracellular space is emerging as a fundamental driving force for cancer growth. Here, we discuss how cancer cells establish and maintain reversed pH gradient, how pH gradient reversal fuels cancer progression, and how these mechanisms can be targeted in cancer therapy.
AB - pH gradient reversal refers to intracellular alkalization and extracellular acidification commonly seen in malignant tumors. To meet their high anabolic demand, cancer cells rewire their glucose metabolism from oxidative phosphorylation to lactate fermentation, which results in the excessive generation of protons. To avoid lethal cytosolic acidification, lactate-fermenting cancer cells activate multiple acid removal pathways leading to the acidification of the extracellular space. This acidification is often further intensified by the defective capacity of the disorganized tumor vasculature to dilute protons away from the cancer tissue. The cancer-specific proton equilibrium with highly alkaline cytosol and acidic extracellular space is emerging as a fundamental driving force for cancer growth. Here, we discuss how cancer cells establish and maintain reversed pH gradient, how pH gradient reversal fuels cancer progression, and how these mechanisms can be targeted in cancer therapy.
KW - Cancer
KW - Cell biology
KW - Glycolysis
KW - Lysosome
KW - pH gradient reversal
U2 - 10.1016/j.biocel.2020.105796
DO - 10.1016/j.biocel.2020.105796
M3 - Review
C2 - 32593663
AN - SCOPUS:85087393984
VL - 125
JO - International Journal of Biochemistry & Cell Biology
JF - International Journal of Biochemistry & Cell Biology
SN - 1357-2725
M1 - 105796
ER -
ID: 244610910