Personal view: Modelling pain mechanisms of migraine without aura
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
Personal view : Modelling pain mechanisms of migraine without aura. / Olesen, Jes.
I: Cephalalgia, Bind 42, Nr. 13, 2022, s. 1425-1435.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Personal view
T2 - Modelling pain mechanisms of migraine without aura
AU - Olesen, Jes
PY - 2022
Y1 - 2022
N2 - Introduction: This review aims to model migraine nociception. Methods: Personal experience and litterature. Results: Genetic and environmental factors in combination decide whether a person suffers from migraine. Endogenous and/or exogenous factors precipitate the individual attacks. Nociception takes place around blood vessels. There is a growing understanding of the molecular pathophysiological mechanisms of migraine from human provocation studies. Rodent models of migraine are necessary to understand the complex interrelation between the many putatively involved molecules and tissues but their relevance for human migraine is uncertain. The crucial element in migraine nociception is a unit consisting of endothelial cells, vascular smooth muscle cells, perivascular nerve fibers (trigeminal, parasympathetic and sympathetic) and mast cells. Attacks may start outside the brain by humoral or neurogenic activity releasing nociceptive substances around blood vessels. They may also (perhaps more often) start by the brain generating efferent activity in autonomic and somatic nerves. Conclusion: Human and rodent studies can quickly uncover the "mystery of migraine".
AB - Introduction: This review aims to model migraine nociception. Methods: Personal experience and litterature. Results: Genetic and environmental factors in combination decide whether a person suffers from migraine. Endogenous and/or exogenous factors precipitate the individual attacks. Nociception takes place around blood vessels. There is a growing understanding of the molecular pathophysiological mechanisms of migraine from human provocation studies. Rodent models of migraine are necessary to understand the complex interrelation between the many putatively involved molecules and tissues but their relevance for human migraine is uncertain. The crucial element in migraine nociception is a unit consisting of endothelial cells, vascular smooth muscle cells, perivascular nerve fibers (trigeminal, parasympathetic and sympathetic) and mast cells. Attacks may start outside the brain by humoral or neurogenic activity releasing nociceptive substances around blood vessels. They may also (perhaps more often) start by the brain generating efferent activity in autonomic and somatic nerves. Conclusion: Human and rodent studies can quickly uncover the "mystery of migraine".
KW - Headache
KW - arteries
KW - CGRP
KW - NO
KW - PACAP
KW - trigeminovascular system
KW - NITRIC-OXIDE
KW - MUSCLE TENDERNESS
KW - HEADACHE
KW - ATTACKS
KW - PATHOPHYSIOLOGY
KW - BLOOD
KW - PHOSPHODIESTERASE-3
KW - HEMODYNAMICS
KW - INHIBITOR
KW - DISORDER
U2 - 10.1177/03331024221111529
DO - 10.1177/03331024221111529
M3 - Review
C2 - 35796522
VL - 42
SP - 1425
EP - 1435
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 13
ER -
ID: 344811762