Peripheral helper T cells in the pathogenesis of multiple sclerosis
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Peripheral helper T cells in the pathogenesis of multiple sclerosis. / Hansen, Rikke Holm; Chow, Helene Hojsgaard; Talbot, Jacob; Buhelt, Sophie; Hellem, Marie Nathalie Nickelsen; Nielsen, Jorgen Erik; Sellebjerg, Finn Thorup; von Essen, Marina Rode.
I: Multiple Sclerosis Journal, Bind 28, Nr. 9, 2022, s. 1340-1350.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Peripheral helper T cells in the pathogenesis of multiple sclerosis
AU - Hansen, Rikke Holm
AU - Chow, Helene Hojsgaard
AU - Talbot, Jacob
AU - Buhelt, Sophie
AU - Hellem, Marie Nathalie Nickelsen
AU - Nielsen, Jorgen Erik
AU - Sellebjerg, Finn Thorup
AU - von Essen, Marina Rode
PY - 2022
Y1 - 2022
N2 - Background: Peripheral helper T cells (Tph) are likely implicated in the pathogenesis of various inflammatory diseases. Tph cells share functions with follicular helper T cells, including plasma cell differentiation and antibody production. Objective and methods: To investigate a possible role of Tph cells in the pathogenesis of multiple sclerosis (MS), we used flow cytometry to analyze the function, phenotype, and central nervous system (CNS)-recruitment of Tph cells in the blood and cerebrospinal fluid (CSF) from controls and patients with relapsing-remitting (RR) and primary progressive (PP) MS. Result: This study identified two functionally distinct Tph cell populations and a regulatory counterpart, Tpr cells. No differences in blood frequencies, cytokine production, or potential to interact with B cells were found between controls and patients with MS. Along with an equal CNS-migration potential, we found both Tph cell populations enriched in the CSF; and surprisingly, an increased frequency of intrathecal Tph cells in the control group compared to patients with MS. Conclusion: Altogether, we did not find an increased frequency of CSF Tph cells in patients with RRMS or PPMS. Our findings indicate that rather than being involved in MS pathogenesis, Tph cells may be implicated in normal CNS immunosurveillance.
AB - Background: Peripheral helper T cells (Tph) are likely implicated in the pathogenesis of various inflammatory diseases. Tph cells share functions with follicular helper T cells, including plasma cell differentiation and antibody production. Objective and methods: To investigate a possible role of Tph cells in the pathogenesis of multiple sclerosis (MS), we used flow cytometry to analyze the function, phenotype, and central nervous system (CNS)-recruitment of Tph cells in the blood and cerebrospinal fluid (CSF) from controls and patients with relapsing-remitting (RR) and primary progressive (PP) MS. Result: This study identified two functionally distinct Tph cell populations and a regulatory counterpart, Tpr cells. No differences in blood frequencies, cytokine production, or potential to interact with B cells were found between controls and patients with MS. Along with an equal CNS-migration potential, we found both Tph cell populations enriched in the CSF; and surprisingly, an increased frequency of intrathecal Tph cells in the control group compared to patients with MS. Conclusion: Altogether, we did not find an increased frequency of CSF Tph cells in patients with RRMS or PPMS. Our findings indicate that rather than being involved in MS pathogenesis, Tph cells may be implicated in normal CNS immunosurveillance.
KW - Multiple sclerosis
KW - peripheral helper T cells
KW - immunosurveillance
KW - immunology
KW - intrathecal antibody production
KW - multiple sclerosis pathogenesis
KW - B-CELLS
KW - GUIDELINES
KW - DIAGNOSIS
KW - CNS
U2 - 10.1177/13524585211067696
DO - 10.1177/13524585211067696
M3 - Journal article
C2 - 35112578
VL - 28
SP - 1340
EP - 1350
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 9
ER -
ID: 314838246