Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease
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Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease. / Adlercreutz, Emma H; Clinical Sciences, Malmö, Lund University, Department; Merlo, Juan; uni, lund.
I: Acta paediatrica (Oslo, Norway : 1992), Bind 104, Nr. 2, 02.2015, s. 178-84.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease
AU - Adlercreutz, Emma H
AU - Clinical Sciences, Malmö, Lund University, Department
AU - Merlo, Juan
AU - uni, lund
N1 - ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
PY - 2015/2
Y1 - 2015/2
N2 - AIM: This study investigated whether perinatal factors influenced the risk of a double diagnosis of type 1 diabetes and coeliac disease.METHODS: We used multinomial logistic regression models to study the associations between perinatal factors, gender, mode of delivery, season of birth and the risk of type 1 diabetes, coeliac disease or both, in Swedish-born singleton children.RESULTS: We found that 4327 of the 768 395 children (0.6%) had been diagnosed with type 1 diabetes, 3817 (0.5%) had been diagnosed with coeliac disease and 191 (0.02%) were affected by both diseases. If the children already had type 1 diabetes (n = 4518), the absolute risk of being affected by coeliac disease increased to 4.2% (n = 191). Children with both type 1 diabetes and coeliac disease were more likely to be female (OR = 1.48, 95% CI = 1.01-1.97), delivered by Caesarean section (OR = 1.60, 95% CI = 1.07-2.39), have native-born Swedish mothers (OR = 4.84, 95% CI = 1.96-11.97) or be born during the summer months (OR = 1.43, 95% CI = 1.07-1.92).CONCLUSION: The increased risk of being affected by a double diagnosis of type 1 diabetes and coeliac disease was modulated by perinatal risk factors. This suggests that early life events are important when it comes to children with type 1 diabetes also developing coeliac disease.
AB - AIM: This study investigated whether perinatal factors influenced the risk of a double diagnosis of type 1 diabetes and coeliac disease.METHODS: We used multinomial logistic regression models to study the associations between perinatal factors, gender, mode of delivery, season of birth and the risk of type 1 diabetes, coeliac disease or both, in Swedish-born singleton children.RESULTS: We found that 4327 of the 768 395 children (0.6%) had been diagnosed with type 1 diabetes, 3817 (0.5%) had been diagnosed with coeliac disease and 191 (0.02%) were affected by both diseases. If the children already had type 1 diabetes (n = 4518), the absolute risk of being affected by coeliac disease increased to 4.2% (n = 191). Children with both type 1 diabetes and coeliac disease were more likely to be female (OR = 1.48, 95% CI = 1.01-1.97), delivered by Caesarean section (OR = 1.60, 95% CI = 1.07-2.39), have native-born Swedish mothers (OR = 4.84, 95% CI = 1.96-11.97) or be born during the summer months (OR = 1.43, 95% CI = 1.07-1.92).CONCLUSION: The increased risk of being affected by a double diagnosis of type 1 diabetes and coeliac disease was modulated by perinatal risk factors. This suggests that early life events are important when it comes to children with type 1 diabetes also developing coeliac disease.
KW - Adult
KW - Celiac Disease/complications
KW - Cesarean Section/adverse effects
KW - Child, Preschool
KW - Diabetes Mellitus, Type 1/complications
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Logistic Models
KW - Male
KW - Pregnancy
KW - Retrospective Studies
KW - Risk Factors
KW - Seasons
KW - Sweden/epidemiology
KW - Young Adult
U2 - 10.1111/apa.12836
DO - 10.1111/apa.12836
M3 - Journal article
C2 - 25346455
VL - 104
SP - 178
EP - 184
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 2
ER -
ID: 364796030