Patients with Rheumatoid Arthritis Acquire Sustainable Skills for Home Monitoring: A Prospective Dual-country Cohort Study (ELECTOR Clinical Trial I)
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Patients with Rheumatoid Arthritis Acquire Sustainable Skills for Home Monitoring : A Prospective Dual-country Cohort Study (ELECTOR Clinical Trial I). / Skougaard, Marie; Bliddal, Henning; Christensen, Robin; Ellegaard, Karen; Nielsen, Sabrina M; Zavada, Jakub; Oreska, Sabina; Krogh, Niels S; Holm, Christian Cato; Hetland, Merete L; Vencovsky, Jiri; Røgind, Henrik; Taylor, Peter C; Gudbergsen, Henrik.
I: The Journal of rheumatology, Bind 47, Nr. 5, 2020, s. 658-667.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Patients with Rheumatoid Arthritis Acquire Sustainable Skills for Home Monitoring
T2 - A Prospective Dual-country Cohort Study (ELECTOR Clinical Trial I)
AU - Skougaard, Marie
AU - Bliddal, Henning
AU - Christensen, Robin
AU - Ellegaard, Karen
AU - Nielsen, Sabrina M
AU - Zavada, Jakub
AU - Oreska, Sabina
AU - Krogh, Niels S
AU - Holm, Christian Cato
AU - Hetland, Merete L
AU - Vencovsky, Jiri
AU - Røgind, Henrik
AU - Taylor, Peter C
AU - Gudbergsen, Henrik
PY - 2020
Y1 - 2020
N2 - OBJECTIVE: In an eHealth setting, to investigate intra- and interrater reliability and agreement of joint assessments and Disease Activity Score using C-reactive protein (DAS28-CRP) in patients with rheumatoid arthritis (RA) and test the effect of repeated joint assessment training.METHODS: Patients with DAS28-CRP ≤ 5.1 were included in a prospective cohort study (clinicaltrials.gov: NCT02317939). Intrarater reliability and agreement of patient-performed joint counts were assessed through completion of 5 joint assessments over a 2-month period. All patients received training on joint assessment at baseline; only half of the patients received repeated training. A subset of patients was included in an appraisal of interrater reliability and agreement comparing joint assessments completed by patients, healthcare professionals (HCP), and ultrasonography. Cohen's κ coefficients and intraclass correlation coefficients (ICC) were used for quantifying of reliability of joint assessments and DAS28-CRP. Agreement was assessed using Bland-Altman plots.RESULTS: Intrarater reliability was excellent with ICC of 0.87 (95% CI 0.83-0.90) and minimal detectable change of 1.13. ICC for interrater reliability ranged between 0.69 and 0.90 (good to excellent). Patients tended to rate DAS28-CRP slightly higher than HCP. In patients receiving repeated training, a mean difference in DAS28-CRP of -0.08 was observed (limits of agreements of -1.06 and 0.90). After 2 months, reliability between patients and HCP was similar between groups receiving single or repeated training.CONCLUSION: Patient-performed assessments of joints and DAS28-CRP in an eHealth home-monitoring solution were reliable and comparable with HCP. Patients can acquire the necessary skills to conduct a correct joint assessment after initial and thorough training. [clinicaltrials.gov (NCT02317939)].
AB - OBJECTIVE: In an eHealth setting, to investigate intra- and interrater reliability and agreement of joint assessments and Disease Activity Score using C-reactive protein (DAS28-CRP) in patients with rheumatoid arthritis (RA) and test the effect of repeated joint assessment training.METHODS: Patients with DAS28-CRP ≤ 5.1 were included in a prospective cohort study (clinicaltrials.gov: NCT02317939). Intrarater reliability and agreement of patient-performed joint counts were assessed through completion of 5 joint assessments over a 2-month period. All patients received training on joint assessment at baseline; only half of the patients received repeated training. A subset of patients was included in an appraisal of interrater reliability and agreement comparing joint assessments completed by patients, healthcare professionals (HCP), and ultrasonography. Cohen's κ coefficients and intraclass correlation coefficients (ICC) were used for quantifying of reliability of joint assessments and DAS28-CRP. Agreement was assessed using Bland-Altman plots.RESULTS: Intrarater reliability was excellent with ICC of 0.87 (95% CI 0.83-0.90) and minimal detectable change of 1.13. ICC for interrater reliability ranged between 0.69 and 0.90 (good to excellent). Patients tended to rate DAS28-CRP slightly higher than HCP. In patients receiving repeated training, a mean difference in DAS28-CRP of -0.08 was observed (limits of agreements of -1.06 and 0.90). After 2 months, reliability between patients and HCP was similar between groups receiving single or repeated training.CONCLUSION: Patient-performed assessments of joints and DAS28-CRP in an eHealth home-monitoring solution were reliable and comparable with HCP. Patients can acquire the necessary skills to conduct a correct joint assessment after initial and thorough training. [clinicaltrials.gov (NCT02317939)].
U2 - 10.3899/jrheum.181362
DO - 10.3899/jrheum.181362
M3 - Journal article
C2 - 31416921
VL - 47
SP - 658
EP - 667
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 5
ER -
ID: 250539950