P4-ATPases: lipid flippases in cell membranes
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P4-ATPases : lipid flippases in cell membranes. / Lopez Marques, Rosa Laura; Theorin, Lisa; Palmgren, Michael Broberg; Günther-Pomorski, Thomas.
I: Pflügers Archiv - European Journal of Physiology, Bind 466, Nr. 7, 2014, s. 1227-1240.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - P4-ATPases
T2 - lipid flippases in cell membranes
AU - Lopez Marques, Rosa Laura
AU - Theorin, Lisa
AU - Palmgren, Michael Broberg
AU - Günther-Pomorski, Thomas
N1 - OA
PY - 2014
Y1 - 2014
N2 - Cellular membranes, notably eukaryotic plasma membranes, are equipped with special proteins that actively translocate lipids from one leaflet to the other and thereby help generate membrane lipid asymmetry. Among these ATP-driven transporters, the P4 subfamily of P-type ATPases (P4-ATPases) comprises lipid flippases that catalyze the translocation of phospholipids from the exoplasmic to the cytosolic leaflet of cell membranes. While initially characterized as aminophospholipid translocases, recent studies of individual P4-ATPase family members from fungi, plants, and animals show that P4-ATPases differ in their substrate specificities and mediate transport of a broader range of lipid substrates, including lysophospholipids and synthetic alkylphospholipids. At the same time, the cellular processes known to be directly or indirectly affected by this class of transporters have expanded to include the regulation of membrane traffic, cytoskeletal dynamics, cell division, lipid metabolism, and lipid signaling. In this review, we will summarize the basic features of P4-ATPases and the physiological implications of their lipid transport activity in the cell.
AB - Cellular membranes, notably eukaryotic plasma membranes, are equipped with special proteins that actively translocate lipids from one leaflet to the other and thereby help generate membrane lipid asymmetry. Among these ATP-driven transporters, the P4 subfamily of P-type ATPases (P4-ATPases) comprises lipid flippases that catalyze the translocation of phospholipids from the exoplasmic to the cytosolic leaflet of cell membranes. While initially characterized as aminophospholipid translocases, recent studies of individual P4-ATPase family members from fungi, plants, and animals show that P4-ATPases differ in their substrate specificities and mediate transport of a broader range of lipid substrates, including lysophospholipids and synthetic alkylphospholipids. At the same time, the cellular processes known to be directly or indirectly affected by this class of transporters have expanded to include the regulation of membrane traffic, cytoskeletal dynamics, cell division, lipid metabolism, and lipid signaling. In this review, we will summarize the basic features of P4-ATPases and the physiological implications of their lipid transport activity in the cell.
KW - CDC50 protein
KW - Flippase
KW - Importer
KW - Lipid asymmetry
KW - P-type pump
KW - Vesicle biogenesis
U2 - 10.1007/s00424-013-1363-4
DO - 10.1007/s00424-013-1363-4
M3 - Journal article
C2 - 24077738
AN - SCOPUS:84904657025
VL - 466
SP - 1227
EP - 1240
JO - Pflügers Archiv - European Journal of Physiology
JF - Pflügers Archiv - European Journal of Physiology
SN - 0031-6768
IS - 7
ER -
ID: 130638694