Outcomes and toxicity of allogeneic hematopoietic cell transplantation in chronic myeloid leukemia patients previously treated with second-generation tyrosine kinase inhibitors: a prospective non-interventional study from the Chronic Malignancy Working Party of the EBMT
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Outcomes and toxicity of allogeneic hematopoietic cell transplantation in chronic myeloid leukemia patients previously treated with second-generation tyrosine kinase inhibitors : a prospective non-interventional study from the Chronic Malignancy Working Party of the EBMT. / Masouridi-Levrat, Stavroula; Olavarria, Eduardo; Iacobelli, Simona; Aljurf, Mahmoud; Morozova, Elena; Niittyvuopio, Riitta; Sengeloev, Henrik; Reményi, Peter; Helbig, Grzegorz; Browne, Paul; Ganser, Arnold; Nagler, Arnon; Snowden, John A.; Robin, Marie; Passweg, Jakob; Van Gorkom, Gwendolyn; Wallet, Hélène Labussière; Hoek, Jennifer; Blok, Henric Jan; De Witte, Theo; Kroeger, Nicolaus; Hayden, Patrick; Chalandon, Yves; Agha, Ibrahim Yakoub.
I: Bone Marrow Transplantation, Bind 57, Nr. 1, 2022, s. 23-30.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Outcomes and toxicity of allogeneic hematopoietic cell transplantation in chronic myeloid leukemia patients previously treated with second-generation tyrosine kinase inhibitors
T2 - a prospective non-interventional study from the Chronic Malignancy Working Party of the EBMT
AU - Masouridi-Levrat, Stavroula
AU - Olavarria, Eduardo
AU - Iacobelli, Simona
AU - Aljurf, Mahmoud
AU - Morozova, Elena
AU - Niittyvuopio, Riitta
AU - Sengeloev, Henrik
AU - Reményi, Peter
AU - Helbig, Grzegorz
AU - Browne, Paul
AU - Ganser, Arnold
AU - Nagler, Arnon
AU - Snowden, John A.
AU - Robin, Marie
AU - Passweg, Jakob
AU - Van Gorkom, Gwendolyn
AU - Wallet, Hélène Labussière
AU - Hoek, Jennifer
AU - Blok, Henric Jan
AU - De Witte, Theo
AU - Kroeger, Nicolaus
AU - Hayden, Patrick
AU - Chalandon, Yves
AU - Agha, Ibrahim Yakoub
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2022
Y1 - 2022
N2 - Allogeneic hematopoietic cell transplantation (allo-HCT) remains a treatment option for patients with chronic myeloid leukemia (CML) who fail to respond to tyrosine kinase inhibitors (TKIs). While imatinib seems to have no adverse impact on outcomes after transplant, little is known on the effects of prior use of second-generation TKI (2GTKI). We present the results of a prospective non-interventional study performed by the EBMT on 383 consecutive CML patients previously treated with dasatinib or nilotinib undergoing allo-HCT from 2009 to 2013. The median age was 45 years (18–68). Disease status at transplant was CP1 in 139 patients (38%), AP or >CP1 in 163 (45%), and BC in 59 (16%). The choice of 2GTKI was: 40% dasatinib, 17% nilotinib, and 43% a sequential treatment of dasatinib and nilotinib with or without bosutinib/ponatinib. With a median follow-up of 37 months (1–77), 8% of patients developed either primary or secondary graft failure, 34% acute and 60% chronic GvHD. There were no differences in post-transplant complications between the three different 2GTKI subgroups. Non-relapse mortality was 18% and 24% at 12 months and at 5 years, respectively. Relapse incidence was 36%, overall survival 56% and relapse-free survival 40% at 5 years. No differences in post-transplant outcomes were found between the three different 2GTKI subgroups. This prospective study demonstrates the feasibility of allo-HCT in patients previously treated with 2GTKI with a post-transplant complications rate comparable to that of TKI-naive or imatinib-treated patients.
AB - Allogeneic hematopoietic cell transplantation (allo-HCT) remains a treatment option for patients with chronic myeloid leukemia (CML) who fail to respond to tyrosine kinase inhibitors (TKIs). While imatinib seems to have no adverse impact on outcomes after transplant, little is known on the effects of prior use of second-generation TKI (2GTKI). We present the results of a prospective non-interventional study performed by the EBMT on 383 consecutive CML patients previously treated with dasatinib or nilotinib undergoing allo-HCT from 2009 to 2013. The median age was 45 years (18–68). Disease status at transplant was CP1 in 139 patients (38%), AP or >CP1 in 163 (45%), and BC in 59 (16%). The choice of 2GTKI was: 40% dasatinib, 17% nilotinib, and 43% a sequential treatment of dasatinib and nilotinib with or without bosutinib/ponatinib. With a median follow-up of 37 months (1–77), 8% of patients developed either primary or secondary graft failure, 34% acute and 60% chronic GvHD. There were no differences in post-transplant complications between the three different 2GTKI subgroups. Non-relapse mortality was 18% and 24% at 12 months and at 5 years, respectively. Relapse incidence was 36%, overall survival 56% and relapse-free survival 40% at 5 years. No differences in post-transplant outcomes were found between the three different 2GTKI subgroups. This prospective study demonstrates the feasibility of allo-HCT in patients previously treated with 2GTKI with a post-transplant complications rate comparable to that of TKI-naive or imatinib-treated patients.
U2 - 10.1038/s41409-021-01472-x
DO - 10.1038/s41409-021-01472-x
M3 - Journal article
C2 - 34599284
AN - SCOPUS:85116345609
VL - 57
SP - 23
EP - 30
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 1
ER -
ID: 346595687