Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Optimal timing of influenza vaccine during pregnancy : A systematic review and meta-analysis. / Cuningham, Will; Geard, Nicholas; Fielding, James E.; Braat, Sabine; Madhi, Shabir A.; Nunes, Marta C.; Christian, Lisa M.; Lin, Shin Yu; Lee, Chien Nan; Yamaguchi, Koushi; Bisgaard, Hans; Chawes, Bo; Chao, An Shine; Blanchard-Rohner, Geraldine; Schlaudecker, Elizabeth P.; Fisher, Barbra M.; McVernon, Jodie; Moss, Robert.
I: Influenza and Other Respiratory Viruses, Bind 13, Nr. 5, 2019, s. 438-452.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Optimal timing of influenza vaccine during pregnancy
T2 - A systematic review and meta-analysis
AU - Cuningham, Will
AU - Geard, Nicholas
AU - Fielding, James E.
AU - Braat, Sabine
AU - Madhi, Shabir A.
AU - Nunes, Marta C.
AU - Christian, Lisa M.
AU - Lin, Shin Yu
AU - Lee, Chien Nan
AU - Yamaguchi, Koushi
AU - Bisgaard, Hans
AU - Chawes, Bo
AU - Chao, An Shine
AU - Blanchard-Rohner, Geraldine
AU - Schlaudecker, Elizabeth P.
AU - Fisher, Barbra M.
AU - McVernon, Jodie
AU - Moss, Robert
PY - 2019
Y1 - 2019
N2 - Background: Pregnant women have an elevated risk of illness and hospitalisation from influenza. Pregnant women are recommended to be prioritised for influenza vaccination during any stage of pregnancy. The risk of seasonal influenza varies substantially throughout the year in temperate climates; however, there is limited knowledge of how vaccination timing during pregnancy impacts the benefits received by the mother and foetus. Objectives: To compare antenatal vaccination timing with regard to influenza vaccine immunogenicity during pregnancy and transplacental transfer to their newborns. Methods: Studies were eligible for inclusion if immunogenicity to influenza vaccine was evaluated in women stratified by trimester of pregnancy. Haemagglutination inhibition (HI) titres, stratified by trimester of vaccination, had to be measured at either pre-vaccination and within one month post-vaccination, post-vaccination and at delivery in the mother, or in cord/newborn blood. Authors searched PubMed, Scopus, Web of Science and EMBASE databases from inception until June 2016 and authors of identified studies were contacted for additional data. Extracted data were tabulated and summarised via random-effect meta-analyses and qualitative methods. Results: Sixteen studies met the inclusion criteria. Meta-analyses found that compared with women vaccinated in an earlier trimester, those vaccinated in a later trimester had a greater fold increase in HI titres (1.33- to 1.96-fold) and higher HI titres in cord/newborn blood (1.21- to 1.64-fold). Conclusions: This review provides comparative analysis of the effect of vaccination timing on maternal immunogenicity and protection of the infant that is informative and relevant to current vaccine scheduling for pregnant women.
AB - Background: Pregnant women have an elevated risk of illness and hospitalisation from influenza. Pregnant women are recommended to be prioritised for influenza vaccination during any stage of pregnancy. The risk of seasonal influenza varies substantially throughout the year in temperate climates; however, there is limited knowledge of how vaccination timing during pregnancy impacts the benefits received by the mother and foetus. Objectives: To compare antenatal vaccination timing with regard to influenza vaccine immunogenicity during pregnancy and transplacental transfer to their newborns. Methods: Studies were eligible for inclusion if immunogenicity to influenza vaccine was evaluated in women stratified by trimester of pregnancy. Haemagglutination inhibition (HI) titres, stratified by trimester of vaccination, had to be measured at either pre-vaccination and within one month post-vaccination, post-vaccination and at delivery in the mother, or in cord/newborn blood. Authors searched PubMed, Scopus, Web of Science and EMBASE databases from inception until June 2016 and authors of identified studies were contacted for additional data. Extracted data were tabulated and summarised via random-effect meta-analyses and qualitative methods. Results: Sixteen studies met the inclusion criteria. Meta-analyses found that compared with women vaccinated in an earlier trimester, those vaccinated in a later trimester had a greater fold increase in HI titres (1.33- to 1.96-fold) and higher HI titres in cord/newborn blood (1.21- to 1.64-fold). Conclusions: This review provides comparative analysis of the effect of vaccination timing on maternal immunogenicity and protection of the infant that is informative and relevant to current vaccine scheduling for pregnant women.
KW - immunogenicity
KW - influenza
KW - pregnancy
KW - timing
KW - trimester
KW - vaccination
U2 - 10.1111/irv.12649
DO - 10.1111/irv.12649
M3 - Review
C2 - 31165580
AN - SCOPUS:85067081159
VL - 13
SP - 438
EP - 452
JO - Influenza and other Respiratory Viruses
JF - Influenza and other Respiratory Viruses
SN - 1750-2640
IS - 5
ER -
ID: 236217772