Occupational physical activity predicts baseline and 8-year progression of carotid atherosclerosis among women
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Occupational physical activity predicts baseline and 8-year progression of carotid atherosclerosis among women. / Korshøj, Mette; Allesøe, Karen; Mortensen, Ole Steen; Siersma, Volkert; Kauhanen, Jussi; Krause, Niklas.
I: Scandinavian Journal of Medicine and Science in Sports, Bind 33, Nr. 9, 2023, s. 1792-1806.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Occupational physical activity predicts baseline and 8-year progression of carotid atherosclerosis among women
AU - Korshøj, Mette
AU - Allesøe, Karen
AU - Mortensen, Ole Steen
AU - Siersma, Volkert
AU - Kauhanen, Jussi
AU - Krause, Niklas
N1 - Publisher Copyright: © 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Introduction: Recent reviews link higher levels of occupational physical activity (OPA) to cardiovascular disease (CVD). However, the evidence for women is inconsistent and studies of activity-limiting symptomatic CVD are prone to healthy worker survivor effect. To address these limitations, this study investigated OPA effects on asymptomatic carotid artery intima–media thickness (IMT) among women. Methods: Participants include 905 women from the population-based Kuopio Ischemic Heart Disease Risk Factor Study with baseline (1998–2001) data on self-reported OPA and sonographic measurement of IMT. Linear mixed models with adjustment for 15 potential confounders estimated and compared mean baseline IMT and 8-year IMT progression for five levels of self-reported OPA. Analyses stratified by cardiovascular health and retirement status were planned because strong interactions between preexisting CVD and OPA intensity have previously been reported. Results: Light standing work, moderately heavy active work, and heavy or very heavy physical work were all consistently associated with greater baseline IMT and 8-year IMT progression than light sitting work. The greatest baseline IMT was observed for heavy or very heavy physical work (1.21 mm), and the greatest 8-year IMT progression for light standing work and moderately heavy active work (both 0.13 mm), 30% above sitting work (0.10 mm). Stratified analyses showed that these differences were driven by much stronger OPA effects among women with baseline carotid artery stenosis. Retired women experienced slower IMT progression than those working at baseline. Conclusions: Higher levels of OPA predict higher baseline IMT and 8-year IMT progression, especially among women with baseline stenosis.
AB - Introduction: Recent reviews link higher levels of occupational physical activity (OPA) to cardiovascular disease (CVD). However, the evidence for women is inconsistent and studies of activity-limiting symptomatic CVD are prone to healthy worker survivor effect. To address these limitations, this study investigated OPA effects on asymptomatic carotid artery intima–media thickness (IMT) among women. Methods: Participants include 905 women from the population-based Kuopio Ischemic Heart Disease Risk Factor Study with baseline (1998–2001) data on self-reported OPA and sonographic measurement of IMT. Linear mixed models with adjustment for 15 potential confounders estimated and compared mean baseline IMT and 8-year IMT progression for five levels of self-reported OPA. Analyses stratified by cardiovascular health and retirement status were planned because strong interactions between preexisting CVD and OPA intensity have previously been reported. Results: Light standing work, moderately heavy active work, and heavy or very heavy physical work were all consistently associated with greater baseline IMT and 8-year IMT progression than light sitting work. The greatest baseline IMT was observed for heavy or very heavy physical work (1.21 mm), and the greatest 8-year IMT progression for light standing work and moderately heavy active work (both 0.13 mm), 30% above sitting work (0.10 mm). Stratified analyses showed that these differences were driven by much stronger OPA effects among women with baseline carotid artery stenosis. Retired women experienced slower IMT progression than those working at baseline. Conclusions: Higher levels of OPA predict higher baseline IMT and 8-year IMT progression, especially among women with baseline stenosis.
KW - atherosclerosis
KW - cardiovascular diseases
KW - cardiovascular mortality
KW - epidemiology
KW - occupational health and safety
KW - physical strain at work
KW - population-based
KW - prevention of cardiovascular disease
KW - prospective study
KW - strenuousness of physical work
KW - women
KW - work environment
U2 - 10.1111/sms.14429
DO - 10.1111/sms.14429
M3 - Journal article
C2 - 37329198
AN - SCOPUS:85162256052
VL - 33
SP - 1792
EP - 1806
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - 9
ER -
ID: 358546879