Normal tension glaucoma and Alzheimer disease: comorbidity?
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Normal tension glaucoma and Alzheimer disease : comorbidity? / Bach-Holm, Daniella; Kessing, Svend Vedel; Mogensen, Ulla; Forman, Julie Lyng; Andersen, Per Kragh; Kessing, Lars Vedel.
I: Acta Ophthamologica (Online), Bind 90, Nr. 7, 11.2012, s. 683-5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Normal tension glaucoma and Alzheimer disease
T2 - comorbidity?
AU - Bach-Holm, Daniella
AU - Kessing, Svend Vedel
AU - Mogensen, Ulla
AU - Forman, Julie Lyng
AU - Andersen, Per Kragh
AU - Kessing, Lars Vedel
N1 - © 2011 The Authors. Acta Ophthalmologica © 2011 Acta Ophthalmologica Scandinavica Foundation.
PY - 2012/11
Y1 - 2012/11
N2 - PURPOSE: To investigate whether normal tension glaucoma (NTG) is associated with increased risk of developing dementia/Alzheimer disease (AD).METHODS: A total of 69 patients with NTG were identified in the case note files in the Glaucoma Clinic, University Hospital of Copenhagen (Rigshospitalet), Denmark from 1980 to 2001. The rate of a subsequent diagnosis of dementia as recorded in nationwide health care registers from 1980 to 2005 was estimated and compared with the rate for the general population [standard mortality rate (SMR) = observed number of cases of dementia/expected number of cases of dementia].RESULTS: The 69 patients had a median age of 64 years (quartiles 57 and 73) at the time of the diagnosis, and the average follow-up period was 12.7 years. The SMR(dementia) was 0.20 (95% CI 0.01-1.11). No patient developed AD.CONCLUSION: Normal tension glaucoma was not associated with an increased risk of developing dementia/AD.
AB - PURPOSE: To investigate whether normal tension glaucoma (NTG) is associated with increased risk of developing dementia/Alzheimer disease (AD).METHODS: A total of 69 patients with NTG were identified in the case note files in the Glaucoma Clinic, University Hospital of Copenhagen (Rigshospitalet), Denmark from 1980 to 2001. The rate of a subsequent diagnosis of dementia as recorded in nationwide health care registers from 1980 to 2005 was estimated and compared with the rate for the general population [standard mortality rate (SMR) = observed number of cases of dementia/expected number of cases of dementia].RESULTS: The 69 patients had a median age of 64 years (quartiles 57 and 73) at the time of the diagnosis, and the average follow-up period was 12.7 years. The SMR(dementia) was 0.20 (95% CI 0.01-1.11). No patient developed AD.CONCLUSION: Normal tension glaucoma was not associated with an increased risk of developing dementia/AD.
KW - Aged
KW - Aged, 80 and over
KW - Alzheimer Disease
KW - Antihypertensive Agents
KW - Ciliary Body
KW - Comorbidity
KW - Denmark
KW - Female
KW - Humans
KW - Intraocular Pressure
KW - Laser Coagulation
KW - Low Tension Glaucoma
KW - Male
KW - Middle Aged
KW - Registries
KW - Risk Factors
KW - Trabeculectomy
U2 - 10.1111/j.1755-3768.2011.02125.x
DO - 10.1111/j.1755-3768.2011.02125.x
M3 - Journal article
C2 - 21332678
VL - 90
SP - 683
EP - 685
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 7
ER -
ID: 140272420