Non-pharmacological modulation of cerebral white matter organization: A systematic review of non-psychiatric and psychiatric studies
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Non-pharmacological modulation of cerebral white matter organization : A systematic review of non-psychiatric and psychiatric studies. / Kristensen, Tina D; Mandl, Rene C W; Jepsen, Jens R M; Rostrup, Egill; Glenthøj, Louise B; Nordentoft, Merete; Glenthøj, Birte Y; Ebdrup, Bjørn H.
I: Neuroscience and Biobehavioral Reviews, Bind 88, 2018, s. 84-97.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Non-pharmacological modulation of cerebral white matter organization
T2 - A systematic review of non-psychiatric and psychiatric studies
AU - Kristensen, Tina D
AU - Mandl, Rene C W
AU - Jepsen, Jens R M
AU - Rostrup, Egill
AU - Glenthøj, Louise B
AU - Nordentoft, Merete
AU - Glenthøj, Birte Y
AU - Ebdrup, Bjørn H
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018
Y1 - 2018
N2 - OBJECTIVE: Neuroplasticity is a well-described phenomenon, but effects of non-pharmacological interventions on white matter (WM) are unclear. Here we review associations between active non-pharmacological interventions and WM organization in healthy subjects and in psychiatric patients.METHOD: A systematic review of non-psychiatric and psychiatric studies in MEDLINE and EMBASE databases. We included longitudinal, controlled studies in human participants aged 18-60 years published in peer-reviewed journals between 2000 and 2017. Studies required active interventions lasting between one day and one year, targeting cognitive-, motor- or sensory domains. The primary outcome was intervention-related brain changes in diffusion-weighted imaging (DWI) derived measures.RESULTS: We included 25 studies. Twenty studies reported positive findings. Five studies investigated psychiatric patients. Nine randomized, controlled trials (RCTs) reported DWI changes following cognitive interventions. Interventions were too heterogeneous to perform a meta-analysis. Intervention duration of at least eight weeks appeared required to induce consistent WM changes.CONCLUSIONS: Non-pharmacological interventions can induce changes in WM. DWI is a relevant correlate of e.g. cognitive training in prospective, long-term RCTs of psychiatric patients.
AB - OBJECTIVE: Neuroplasticity is a well-described phenomenon, but effects of non-pharmacological interventions on white matter (WM) are unclear. Here we review associations between active non-pharmacological interventions and WM organization in healthy subjects and in psychiatric patients.METHOD: A systematic review of non-psychiatric and psychiatric studies in MEDLINE and EMBASE databases. We included longitudinal, controlled studies in human participants aged 18-60 years published in peer-reviewed journals between 2000 and 2017. Studies required active interventions lasting between one day and one year, targeting cognitive-, motor- or sensory domains. The primary outcome was intervention-related brain changes in diffusion-weighted imaging (DWI) derived measures.RESULTS: We included 25 studies. Twenty studies reported positive findings. Five studies investigated psychiatric patients. Nine randomized, controlled trials (RCTs) reported DWI changes following cognitive interventions. Interventions were too heterogeneous to perform a meta-analysis. Intervention duration of at least eight weeks appeared required to induce consistent WM changes.CONCLUSIONS: Non-pharmacological interventions can induce changes in WM. DWI is a relevant correlate of e.g. cognitive training in prospective, long-term RCTs of psychiatric patients.
U2 - 10.1016/j.neubiorev.2018.03.013
DO - 10.1016/j.neubiorev.2018.03.013
M3 - Review
C2 - 29550210
VL - 88
SP - 84
EP - 97
JO - Neuroscience & Biobehavioral Reviews
JF - Neuroscience & Biobehavioral Reviews
SN - 0149-7634
ER -
ID: 212909558