Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium
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Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium. / Rosenkrantz, Jesper Tjørnhøj; Aarts, Henk; Abee, Tjakko; Rolfe, Matthew D.; Knudsen, Gitte Maegaard; Nielsen, Maj-Britt; Thomsen, Line Elnif; Zwietering, Marcel H.; Olsen, John Elmerdahl; Pin, Carmen.
I: B M C Microbiology, Bind 13, 294, 2013.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium
AU - Rosenkrantz, Jesper Tjørnhøj
AU - Aarts, Henk
AU - Abee, Tjakko
AU - Rolfe, Matthew D.
AU - Knudsen, Gitte Maegaard
AU - Nielsen, Maj-Britt
AU - Thomsen, Line Elnif
AU - Zwietering, Marcel H.
AU - Olsen, John Elmerdahl
AU - Pin, Carmen
PY - 2013
Y1 - 2013
N2 - Salmonella Typhimurium is an important pathogen of human and animals. It shows a broad growth range and survives in harsh conditions. The aim of this study was to analyze transcriptional responses to a number of growth and stress conditions as well as the relationship of metabolic pathways and/or cell functions at the genome-scale-level by network analysis, and further to explore whether highly connected genes (hubs) in these networks were essential for growth, stress adaptation and virulence.
AB - Salmonella Typhimurium is an important pathogen of human and animals. It shows a broad growth range and survives in harsh conditions. The aim of this study was to analyze transcriptional responses to a number of growth and stress conditions as well as the relationship of metabolic pathways and/or cell functions at the genome-scale-level by network analysis, and further to explore whether highly connected genes (hubs) in these networks were essential for growth, stress adaptation and virulence.
KW - Faculty of Health and Medical Sciences
KW - Salmonella
KW - regulation
KW - metabolism
KW - genom scale network
U2 - 10.1186/1471-2180-13-294
DO - 10.1186/1471-2180-13-294
M3 - Journal article
C2 - 24345035
VL - 13
JO - BMC Microbiology
JF - BMC Microbiology
SN - 1471-2180
M1 - 294
ER -
ID: 92299428