TY - JOUR

T1 - No effect on survival of home psychosocial intervention in a randomized study of Danish colorectal cancer patients

AU - Ross, Lone

AU - Frederiksen, Kirsten

AU - Boesen, Sidsel H

AU - Karlsen, Randi V

AU - Rasmussen, Morten S

AU - Sørensen, Lars T

AU - Jørgensen, Torben

AU - Claesson, Mogens H

AU - Johansen, Christoffer

N1 - Times Cited: 0ArticleEnglishRoss, LBispebjerg Hosp, Dept Palliat Med, Res Unit, DK-2400 Copenhagen NV, DenmarkCited References Count: 37485EHJOHN WILEY & SONS LTDTHE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLANDCHICHESTER

PY - 2009

Y1 - 2009

N2 - Objective: We investigated whether regular home visits to persons with newly diagnosed colorectal cancer influenced their overall survival and selected immune parameters.Methods: A total of 249 Danish colorectal cancer patients undergoing abdominal surgery were randomly assigned to a control or an intervention group. The intervention group received 10 home visits from a project nurse or a medical doctor during the first 2 years after discharge. The home visits aimed at providing emotional support and information. A subgroup of 55 patients provided blood samples 3, 12 and 24 months after discharge for measurement of immune parameters. Survival was assessed 6.5-9.5 years after the first operation.Results: A total of 148 patients died during follow-up. The intervention was not significantly associated with survival (p=0.68) after adjustment for Dukes' stage, radicality of the operation, age, sex, family social class and marital status. Likewise, no significant interactions were found between group and these covariates (all p>/=0.08). In the substudy of the possible effect of the intervention on immune parameters, there were no differences between the two groups with respect to lymphocyte proliferation (all p>/=0.078) or natural killer cell activity (all p>/=0.33) and no consistent effect on the number of specific subsets of cells (phenotypes) during follow-up.Conclusion: The study failed to provide evidence that the psychosocial intervention provided as home visits significantly affected the prognosis or selected immune parameters of patients who had undergone surgery for colorectal cancer. Copyright (c) 2009 John Wiley & Sons, Ltd.

AB - Objective: We investigated whether regular home visits to persons with newly diagnosed colorectal cancer influenced their overall survival and selected immune parameters.Methods: A total of 249 Danish colorectal cancer patients undergoing abdominal surgery were randomly assigned to a control or an intervention group. The intervention group received 10 home visits from a project nurse or a medical doctor during the first 2 years after discharge. The home visits aimed at providing emotional support and information. A subgroup of 55 patients provided blood samples 3, 12 and 24 months after discharge for measurement of immune parameters. Survival was assessed 6.5-9.5 years after the first operation.Results: A total of 148 patients died during follow-up. The intervention was not significantly associated with survival (p=0.68) after adjustment for Dukes' stage, radicality of the operation, age, sex, family social class and marital status. Likewise, no significant interactions were found between group and these covariates (all p>/=0.08). In the substudy of the possible effect of the intervention on immune parameters, there were no differences between the two groups with respect to lymphocyte proliferation (all p>/=0.078) or natural killer cell activity (all p>/=0.33) and no consistent effect on the number of specific subsets of cells (phenotypes) during follow-up.Conclusion: The study failed to provide evidence that the psychosocial intervention provided as home visits significantly affected the prognosis or selected immune parameters of patients who had undergone surgery for colorectal cancer. Copyright (c) 2009 John Wiley & Sons, Ltd.

U2 - 10.1002/pon.1524

DO - 10.1002/pon.1524

M3 - Journal article

C2 - 19137506

JO - Psycho-Oncology

JF - Psycho-Oncology

SN - 1057-9249

ER -