Newborn regional body composition is influenced by maternal obesity, gestational weight gain and the birthweight standard score
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Newborn regional body composition is influenced by maternal obesity, gestational weight gain and the birthweight standard score. / Carlsen, E M; Renault, Kristina Martha; Nørgaard, K; Nilas, Lisbeth; Jensen, J E B; Hyldstrup, L; Michaelsen, Kim F.; Cortes, Dina; Pryds, Ole.
I: Acta Paediatrica, Bind 103, Nr. 9, 2014, s. 939-945.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Newborn regional body composition is influenced by maternal obesity, gestational weight gain and the birthweight standard score
AU - Carlsen, E M
AU - Renault, Kristina Martha
AU - Nørgaard, K
AU - Nilas, Lisbeth
AU - Jensen, J E B
AU - Hyldstrup, L
AU - Michaelsen, Kim F.
AU - Cortes, Dina
AU - Pryds, Ole
N1 - CURIS 2014 NEXS 266
PY - 2014
Y1 - 2014
N2 - AIM: This study investigated whether newborn body composition is influenced by prepregnancy obesity and gestational weight gain (GWG) and explored any associations between body composition and birthweight standard score (z-score), categorised by size for gestational age.METHODS: We recruited 231 obese and 80 normal weight mothers and their newborn infants and assessed the babies' body composition using dual-energy X-ray absorptiometry.RESULTS: The total and abdominal fat masses of infants born to mother who were obese before pregnancy were 135 g (p < 0.001) and 18 g (p < 0.001) higher than the offspring of normal weight mothers. The infants' fat mass increased by 11 g (p < 0.001) for every kilogram of GWG. There were no associations between prepregnancy obesity and fat-free mass. The fat percentage was significantly higher in infants who were large for gestational age (15.3%) than small for gestational age (5.2%) and appropriate for gestational age (9.8%) (p < 0.001). Lower birthweight z-score was associated with a higher proportion of abdominal fat mass (p = 0.009).CONCLUSION: Infants born to obese mothers had higher fat mass at birth, with abdominal fat accumulation. Low birthweight was associated with a lower crude abdominal fat mass, but a higher proportion of total fat mass placed abdominally.
AB - AIM: This study investigated whether newborn body composition is influenced by prepregnancy obesity and gestational weight gain (GWG) and explored any associations between body composition and birthweight standard score (z-score), categorised by size for gestational age.METHODS: We recruited 231 obese and 80 normal weight mothers and their newborn infants and assessed the babies' body composition using dual-energy X-ray absorptiometry.RESULTS: The total and abdominal fat masses of infants born to mother who were obese before pregnancy were 135 g (p < 0.001) and 18 g (p < 0.001) higher than the offspring of normal weight mothers. The infants' fat mass increased by 11 g (p < 0.001) for every kilogram of GWG. There were no associations between prepregnancy obesity and fat-free mass. The fat percentage was significantly higher in infants who were large for gestational age (15.3%) than small for gestational age (5.2%) and appropriate for gestational age (9.8%) (p < 0.001). Lower birthweight z-score was associated with a higher proportion of abdominal fat mass (p = 0.009).CONCLUSION: Infants born to obese mothers had higher fat mass at birth, with abdominal fat accumulation. Low birthweight was associated with a lower crude abdominal fat mass, but a higher proportion of total fat mass placed abdominally.
U2 - 10.1111/apa.12713
DO - 10.1111/apa.12713
M3 - Journal article
C2 - 24942370
VL - 103
SP - 939
EP - 945
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 9
ER -
ID: 123729639