Neuroimaging in 205 consecutive Children Diagnosed with Central Precocious Puberty in Denmark
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Neuroimaging in 205 consecutive Children Diagnosed with Central Precocious Puberty in Denmark. / Hansen, Anna B.; Renault, Christoffer H.; Wojdemann, Ditte; Gideon, Peter; Juul, Anders; Jensen, Rikke Beck.
I: Pediatric Research, Bind 93, 2023, s. 125–130.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Neuroimaging in 205 consecutive Children Diagnosed with Central Precocious Puberty in Denmark
AU - Hansen, Anna B.
AU - Renault, Christoffer H.
AU - Wojdemann, Ditte
AU - Gideon, Peter
AU - Juul, Anders
AU - Jensen, Rikke Beck
PY - 2023
Y1 - 2023
N2 - Introduction A brain magnetic resonance image (MRI) is considered part of routine evaluation in children diagnosed with central precocious puberty (CPP) to rule out intracranial pathology. We evaluated the occurrence of pathological findings on neuroimaging among children diagnosed with CPP. Methods A retrospective study based on an evaluation of 1544 children referred with early signs of puberty from 2009-2019. Of these, 205 children (29 boys) with confirmed CPP had a brain MRI performed, and we report MRI results, pubertal stage, bone age, and hormonal analyses. All abnormal MRI results were re-evaluated by a trained neuroradiologist. Results A new intracranial pathology was found by brain MRI in 6 out of 205 patients aged 1.5 to 6.1 years. The occurrence of intracranial pathology was 3/162 (1.8%) and 3/24 (12.5 %) in girls and boys respectively. Conclusion Organic causes of precocious puberty are more frequent in boys with CPP than in girls. No cases of organic CPP were seen above age 6.1 years of age. The age cut off value for routine brain MRI could be lowered to seven or perhaps even six years of age for girls, except in rapidly progressing puberty or presence of neurological symptoms. Impact In our study of children with central precocious puberty (CPP), intracranial pathology is a rare cause and occurs only in younger children. It supports the general trend, that younger children are at higher risk of having organic causes to CPP and supports the clinical practice, that only high-risk patients with CPP should undergo routine brain MRI.
AB - Introduction A brain magnetic resonance image (MRI) is considered part of routine evaluation in children diagnosed with central precocious puberty (CPP) to rule out intracranial pathology. We evaluated the occurrence of pathological findings on neuroimaging among children diagnosed with CPP. Methods A retrospective study based on an evaluation of 1544 children referred with early signs of puberty from 2009-2019. Of these, 205 children (29 boys) with confirmed CPP had a brain MRI performed, and we report MRI results, pubertal stage, bone age, and hormonal analyses. All abnormal MRI results were re-evaluated by a trained neuroradiologist. Results A new intracranial pathology was found by brain MRI in 6 out of 205 patients aged 1.5 to 6.1 years. The occurrence of intracranial pathology was 3/162 (1.8%) and 3/24 (12.5 %) in girls and boys respectively. Conclusion Organic causes of precocious puberty are more frequent in boys with CPP than in girls. No cases of organic CPP were seen above age 6.1 years of age. The age cut off value for routine brain MRI could be lowered to seven or perhaps even six years of age for girls, except in rapidly progressing puberty or presence of neurological symptoms. Impact In our study of children with central precocious puberty (CPP), intracranial pathology is a rare cause and occurs only in younger children. It supports the general trend, that younger children are at higher risk of having organic causes to CPP and supports the clinical practice, that only high-risk patients with CPP should undergo routine brain MRI.
KW - GIRLS
KW - PREVALENCE
KW - PATTERN
KW - PREDICT
KW - ONSET
KW - SEX
KW - AGE
U2 - 10.1038/s41390-022-02047-2
DO - 10.1038/s41390-022-02047-2
M3 - Journal article
C2 - 35365758
VL - 93
SP - 125
EP - 130
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
ER -
ID: 308078369