Neurobehavioral deficits at age 7years associated with prenatal exposure to toxicants from maternal seafood diet
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Neurobehavioral deficits at age 7years associated with prenatal exposure to toxicants from maternal seafood diet. / Grandjean, Philippe; Weihe, Pal; Nielsen, Flemming; Heinzow, Birger; Debes, Frodi; Budtz-Jørgensen, Esben.
I: Neurotoxicology and Teratology, Bind 34, Nr. 4, 06.2012, s. 466-472.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Neurobehavioral deficits at age 7years associated with prenatal exposure to toxicants from maternal seafood diet
AU - Grandjean, Philippe
AU - Weihe, Pal
AU - Nielsen, Flemming
AU - Heinzow, Birger
AU - Debes, Frodi
AU - Budtz-Jørgensen, Esben
N1 - Copyright © 2012. Published by Elsevier Inc.
PY - 2012/6
Y1 - 2012/6
N2 - To determine the possible neurotoxic impact of prenatal exposure to polychlorinated biphenyls (PCBs), we analyzed banked cord blood from a Faroese birth cohort for PCBs. The subjects were born in 1986-1987, and 917 cohort members had completed a series of neuropsychological tests at age 7years. Major PCB congeners (118, 138, 153, and 180), the calculated total PCB concentration, and the PCB exposure estimated in a structural equation model showed weak associations with test deficits, with statistically significant negative associations only with the Boston Naming test. Likewise, neither hexachlorobenzene nor p,p'-dichlorodiphenyldichloroethylene showed clear links to neurobehavioral deficits. Thus, these associations were much weaker than those associated with the cord-blood mercury concentration, and adjustment for mercury substantially attenuated the regression coefficients for PCB exposure. When the outcomes were joined into motor and verbally mediated functions in a structural equation model, the PCB effects remained weak and virtually disappeared after adjustment for methylmercury exposure, while mercury remained statistically significant. Thus, in the presence of elevated methylmercury exposure, PCB neurotoxicity may be difficult to detect, and PCB exposure does not explain the methylmercury neurotoxicity previously reported in this cohort.
AB - To determine the possible neurotoxic impact of prenatal exposure to polychlorinated biphenyls (PCBs), we analyzed banked cord blood from a Faroese birth cohort for PCBs. The subjects were born in 1986-1987, and 917 cohort members had completed a series of neuropsychological tests at age 7years. Major PCB congeners (118, 138, 153, and 180), the calculated total PCB concentration, and the PCB exposure estimated in a structural equation model showed weak associations with test deficits, with statistically significant negative associations only with the Boston Naming test. Likewise, neither hexachlorobenzene nor p,p'-dichlorodiphenyldichloroethylene showed clear links to neurobehavioral deficits. Thus, these associations were much weaker than those associated with the cord-blood mercury concentration, and adjustment for mercury substantially attenuated the regression coefficients for PCB exposure. When the outcomes were joined into motor and verbally mediated functions in a structural equation model, the PCB effects remained weak and virtually disappeared after adjustment for methylmercury exposure, while mercury remained statistically significant. Thus, in the presence of elevated methylmercury exposure, PCB neurotoxicity may be difficult to detect, and PCB exposure does not explain the methylmercury neurotoxicity previously reported in this cohort.
U2 - 10.1016/j.ntt.2012.06.001
DO - 10.1016/j.ntt.2012.06.001
M3 - Journal article
C2 - 22705177
VL - 34
SP - 466
EP - 472
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
SN - 0892-0362
IS - 4
ER -
ID: 38410878