Neural correlates of executive attention in adults born very preterm
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Neural correlates of executive attention in adults born very preterm. / Daamen, Marcel; Bäuml, Josef G.; Scheef, Lukas; Meng, Chun; Jurcoane, Alina; Jaekel, Julia; Sorg, Christian; Busch, Barbara; Baumann, Nicole; Bartmann, Peter; Wolke, Dieter; Wohlschläger, Afra; Boecker, Henning.
I: NeuroImage: Clinical, Bind 9, 2015, s. 581-591.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Neural correlates of executive attention in adults born very preterm
AU - Daamen, Marcel
AU - Bäuml, Josef G.
AU - Scheef, Lukas
AU - Meng, Chun
AU - Jurcoane, Alina
AU - Jaekel, Julia
AU - Sorg, Christian
AU - Busch, Barbara
AU - Baumann, Nicole
AU - Bartmann, Peter
AU - Wolke, Dieter
AU - Wohlschläger, Afra
AU - Boecker, Henning
N1 - Publisher Copyright: © 2015 The Authors. Published by Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - Very preterm birth is associated with an increased prevalence of attention problems and may especially impair executive attention, i.e., top-down control of attentional selection in situations where distracting information interferes with the processing of task-relevant stimuli. While there are initial findings linking structural brain alterations in preterm-born individuals with attention problems, the functional basis of these problems are not well understood. The present study used an fMRI adaptation of the Attentional Network Test to examine the neural correlates of executive attention in a large sample of N = 86 adults born very preterm and/or with very low birth weight (VP/VLBW), and N = 100 term-born controls. Executive attention was measured by comparing task behavior and brain activations associated with the processing of incongruent vs. congruent arrow flanker stimuli. Consistent with subtle impairments of executive attention, the VP/VLBW group showed lower accuracy and a tendency for increased response times during the processing of incongruent stimuli. Both groups showed similar activation patters, especially within expected fronto-cingulo-parietal areas, but no significant between-group differences. Our results argue for a maintained attention-relevant network organization in high-functioning preterm born adults in spite of subtle deficits in executive attention. Gestational age and neonatal treatment variables showed associations with task behavior, and brain activation in the dorsal ACC and lateral occipital areas, suggesting that the degree of prematurity (and related neonatal complications) has subtle modulatory influences on executive attention processing.
AB - Very preterm birth is associated with an increased prevalence of attention problems and may especially impair executive attention, i.e., top-down control of attentional selection in situations where distracting information interferes with the processing of task-relevant stimuli. While there are initial findings linking structural brain alterations in preterm-born individuals with attention problems, the functional basis of these problems are not well understood. The present study used an fMRI adaptation of the Attentional Network Test to examine the neural correlates of executive attention in a large sample of N = 86 adults born very preterm and/or with very low birth weight (VP/VLBW), and N = 100 term-born controls. Executive attention was measured by comparing task behavior and brain activations associated with the processing of incongruent vs. congruent arrow flanker stimuli. Consistent with subtle impairments of executive attention, the VP/VLBW group showed lower accuracy and a tendency for increased response times during the processing of incongruent stimuli. Both groups showed similar activation patters, especially within expected fronto-cingulo-parietal areas, but no significant between-group differences. Our results argue for a maintained attention-relevant network organization in high-functioning preterm born adults in spite of subtle deficits in executive attention. Gestational age and neonatal treatment variables showed associations with task behavior, and brain activation in the dorsal ACC and lateral occipital areas, suggesting that the degree of prematurity (and related neonatal complications) has subtle modulatory influences on executive attention processing.
KW - Anterior cingulate
KW - Attentional Network Test
KW - Executive attention
KW - Gestational age
KW - Preterm birth
UR - http://www.scopus.com/inward/record.url?scp=84945305108&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2015.09.002
DO - 10.1016/j.nicl.2015.09.002
M3 - Journal article
C2 - 26640769
AN - SCOPUS:84945305108
VL - 9
SP - 581
EP - 591
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
SN - 2213-1582
ER -
ID: 393168918