Neural activation in stress-related exhaustion: Cross-sectional observations and interventional effects
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Neural activation in stress-related exhaustion : Cross-sectional observations and interventional effects. / Gavelin, Hanna Malmberg; Neely, Anna Stigsdotter; Andersson, Micael; Eskilsson, Therese; Järvholm, Lisbeth Slunga; Boraxbekk, Carl Johan.
I: Psychiatry Research - Neuroimaging, Bind 269, 30.11.2017, s. 17-25.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Neural activation in stress-related exhaustion
T2 - Cross-sectional observations and interventional effects
AU - Gavelin, Hanna Malmberg
AU - Neely, Anna Stigsdotter
AU - Andersson, Micael
AU - Eskilsson, Therese
AU - Järvholm, Lisbeth Slunga
AU - Boraxbekk, Carl Johan
N1 - Publisher Copyright: © 2017 Elsevier B.V.
PY - 2017/11/30
Y1 - 2017/11/30
N2 - The primary purpose of this study was to investigate the association between burnout and neural activation during working memory processing in patients with stress-related exhaustion. Additionally, we investigated the neural effects of cognitive training as part of stress rehabilitation. Fifty-five patients with clinical diagnosis of exhaustion disorder were administered the n-back task during fMRI scanning at baseline. Ten patients completed a 12-week cognitive training intervention, as an addition to stress rehabilitation. Eleven patients served as a treatment-as-usual control group. At baseline, burnout level was positively associated with neural activation in the rostral prefrontal cortex, the posterior parietal cortex and the striatum, primarily in the 2-back condition. Following stress rehabilitation, the striatal activity decreased as a function of improved levels of burnout. No significant association between burnout level and working memory performance was found, however, our findings indicate that frontostriatal neural responses related to working memory were modulated by burnout severity. We suggest that patients with high levels of burnout need to recruit additional cognitive resources to uphold task performance. Following cognitive training, increased neural activation was observed during 3-back in working memory-related regions, including the striatum, however, low sample size limits any firm conclusions.
AB - The primary purpose of this study was to investigate the association between burnout and neural activation during working memory processing in patients with stress-related exhaustion. Additionally, we investigated the neural effects of cognitive training as part of stress rehabilitation. Fifty-five patients with clinical diagnosis of exhaustion disorder were administered the n-back task during fMRI scanning at baseline. Ten patients completed a 12-week cognitive training intervention, as an addition to stress rehabilitation. Eleven patients served as a treatment-as-usual control group. At baseline, burnout level was positively associated with neural activation in the rostral prefrontal cortex, the posterior parietal cortex and the striatum, primarily in the 2-back condition. Following stress rehabilitation, the striatal activity decreased as a function of improved levels of burnout. No significant association between burnout level and working memory performance was found, however, our findings indicate that frontostriatal neural responses related to working memory were modulated by burnout severity. We suggest that patients with high levels of burnout need to recruit additional cognitive resources to uphold task performance. Following cognitive training, increased neural activation was observed during 3-back in working memory-related regions, including the striatum, however, low sample size limits any firm conclusions.
KW - Burnout
KW - Cognitive training
KW - Exhaustion disorder
KW - fMRI
KW - Stress rehabilitation
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=85029348801&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2017.08.008
DO - 10.1016/j.pscychresns.2017.08.008
M3 - Journal article
C2 - 28917154
AN - SCOPUS:85029348801
VL - 269
SP - 17
EP - 25
JO - Psychiatry Research: Neuroimaging
JF - Psychiatry Research: Neuroimaging
SN - 0925-4927
ER -
ID: 332186730