Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes: implications for control of asymptomatic malaria infections

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Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes : implications for control of asymptomatic malaria infections. / Fall, Abdou Khadre Dit Jadir; Kana, Ikhlaq Hussain; Dechavanne, Célia; Garcia-Senosiain, Asier; Guitard, Evelyne; Milet, Jacqueline; Massougbodji, Achille; Garcia, André; Dugoujon, Jean-Michel; Migot-Nabias, Florence; Theisen, Michael; Courtin, David.

I: Malaria Journal, Bind 21, 2022, s. 356.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Fall, AKDJ, Kana, IH, Dechavanne, C, Garcia-Senosiain, A, Guitard, E, Milet, J, Massougbodji, A, Garcia, A, Dugoujon, J-M, Migot-Nabias, F, Theisen, M & Courtin, D 2022, 'Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes: implications for control of asymptomatic malaria infections', Malaria Journal, bind 21, s. 356. https://doi.org/10.1186/s12936-022-04361-w

APA

Fall, A. K. D. J., Kana, I. H., Dechavanne, C., Garcia-Senosiain, A., Guitard, E., Milet, J., Massougbodji, A., Garcia, A., Dugoujon, J-M., Migot-Nabias, F., Theisen, M., & Courtin, D. (2022). Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes: implications for control of asymptomatic malaria infections. Malaria Journal, 21, 356. https://doi.org/10.1186/s12936-022-04361-w

Vancouver

Fall AKDJ, Kana IH, Dechavanne C, Garcia-Senosiain A, Guitard E, Milet J o.a. Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes: implications for control of asymptomatic malaria infections. Malaria Journal. 2022;21:356. https://doi.org/10.1186/s12936-022-04361-w

Author

Fall, Abdou Khadre Dit Jadir ; Kana, Ikhlaq Hussain ; Dechavanne, Célia ; Garcia-Senosiain, Asier ; Guitard, Evelyne ; Milet, Jacqueline ; Massougbodji, Achille ; Garcia, André ; Dugoujon, Jean-Michel ; Migot-Nabias, Florence ; Theisen, Michael ; Courtin, David. / Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes : implications for control of asymptomatic malaria infections. I: Malaria Journal. 2022 ; Bind 21. s. 356.

Bibtex

@article{835512ee9acf40588e2d4161519de37d,
title = "Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes: implications for control of asymptomatic malaria infections",
abstract = "BACKGROUND: Immunoglobulin G (IgG) antibodies are thought to play important roles in the protection against Plasmodium falciparum (P. falciparum) malaria. A longitudinal cohort study performed in the Southern part of Benin, identified a group of infants who were able to control asymptomatic malaria infections (CAIG).METHODS: IgG antibodies against distinct merozoite antigens were quantified in plasma from Beninese infants. Functionality of these antibodies was assessed by the merozoite-phagocytosis assay using THP-1 cells and primary neutrophils as effector cells. Gm allotypes were determined by a serological method of haemagglutination inhibition.RESULTS: Purified IgG from infants in CAIG promoted higher levels of merozoite-phagocytosis than did IgG from children who were unable to control asymptomatic infections (Ologit multivariate regression model, Coef. = 0.06, 95% CI 0.02;0.10, P = 0.002). High level of merozoite-phagocytosis activity was significantly associated with high levels of IgG against AMA1 (Coef. = 1.76, 95% CI 0.39;3.14, P = 0.012) and GLURP-R2 (Coef. = 12.24, 95% CI 1.35;23.12, P = 0.028). Moreover, infants of the G3m5,6,10,11,13,14,24 phenotype showed higher merozoite-phagocytosis activity (Generalized linear model multivariate regression, Coef. = 7.46, 95% CI 0.31;14.61, P = 0.041) than those presenting other G3m phenotypes.CONCLUSION: The results of the present study confirm the importance of antibodies to merozoite surface antigens in the control of asymptomatic malaria infection in Beninese infants. The study also demonstrated that G3m phenotypes impact the functional activity of IgG. This last point could have a considerable impact in the research of candidate vaccines against malaria parasites or other pathogens.",
author = "Fall, {Abdou Khadre Dit Jadir} and Kana, {Ikhlaq Hussain} and C{\'e}lia Dechavanne and Asier Garcia-Senosiain and Evelyne Guitard and Jacqueline Milet and Achille Massougbodji and Andr{\'e} Garcia and Jean-Michel Dugoujon and Florence Migot-Nabias and Michael Theisen and David Courtin",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
doi = "10.1186/s12936-022-04361-w",
language = "English",
volume = "21",
pages = "356",
journal = "Malaria Journal",
issn = "1475-2875",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes

T2 - implications for control of asymptomatic malaria infections

AU - Fall, Abdou Khadre Dit Jadir

AU - Kana, Ikhlaq Hussain

AU - Dechavanne, Célia

AU - Garcia-Senosiain, Asier

AU - Guitard, Evelyne

AU - Milet, Jacqueline

AU - Massougbodji, Achille

AU - Garcia, André

AU - Dugoujon, Jean-Michel

AU - Migot-Nabias, Florence

AU - Theisen, Michael

AU - Courtin, David

N1 - © 2022. The Author(s).

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Immunoglobulin G (IgG) antibodies are thought to play important roles in the protection against Plasmodium falciparum (P. falciparum) malaria. A longitudinal cohort study performed in the Southern part of Benin, identified a group of infants who were able to control asymptomatic malaria infections (CAIG).METHODS: IgG antibodies against distinct merozoite antigens were quantified in plasma from Beninese infants. Functionality of these antibodies was assessed by the merozoite-phagocytosis assay using THP-1 cells and primary neutrophils as effector cells. Gm allotypes were determined by a serological method of haemagglutination inhibition.RESULTS: Purified IgG from infants in CAIG promoted higher levels of merozoite-phagocytosis than did IgG from children who were unable to control asymptomatic infections (Ologit multivariate regression model, Coef. = 0.06, 95% CI 0.02;0.10, P = 0.002). High level of merozoite-phagocytosis activity was significantly associated with high levels of IgG against AMA1 (Coef. = 1.76, 95% CI 0.39;3.14, P = 0.012) and GLURP-R2 (Coef. = 12.24, 95% CI 1.35;23.12, P = 0.028). Moreover, infants of the G3m5,6,10,11,13,14,24 phenotype showed higher merozoite-phagocytosis activity (Generalized linear model multivariate regression, Coef. = 7.46, 95% CI 0.31;14.61, P = 0.041) than those presenting other G3m phenotypes.CONCLUSION: The results of the present study confirm the importance of antibodies to merozoite surface antigens in the control of asymptomatic malaria infection in Beninese infants. The study also demonstrated that G3m phenotypes impact the functional activity of IgG. This last point could have a considerable impact in the research of candidate vaccines against malaria parasites or other pathogens.

AB - BACKGROUND: Immunoglobulin G (IgG) antibodies are thought to play important roles in the protection against Plasmodium falciparum (P. falciparum) malaria. A longitudinal cohort study performed in the Southern part of Benin, identified a group of infants who were able to control asymptomatic malaria infections (CAIG).METHODS: IgG antibodies against distinct merozoite antigens were quantified in plasma from Beninese infants. Functionality of these antibodies was assessed by the merozoite-phagocytosis assay using THP-1 cells and primary neutrophils as effector cells. Gm allotypes were determined by a serological method of haemagglutination inhibition.RESULTS: Purified IgG from infants in CAIG promoted higher levels of merozoite-phagocytosis than did IgG from children who were unable to control asymptomatic infections (Ologit multivariate regression model, Coef. = 0.06, 95% CI 0.02;0.10, P = 0.002). High level of merozoite-phagocytosis activity was significantly associated with high levels of IgG against AMA1 (Coef. = 1.76, 95% CI 0.39;3.14, P = 0.012) and GLURP-R2 (Coef. = 12.24, 95% CI 1.35;23.12, P = 0.028). Moreover, infants of the G3m5,6,10,11,13,14,24 phenotype showed higher merozoite-phagocytosis activity (Generalized linear model multivariate regression, Coef. = 7.46, 95% CI 0.31;14.61, P = 0.041) than those presenting other G3m phenotypes.CONCLUSION: The results of the present study confirm the importance of antibodies to merozoite surface antigens in the control of asymptomatic malaria infection in Beninese infants. The study also demonstrated that G3m phenotypes impact the functional activity of IgG. This last point could have a considerable impact in the research of candidate vaccines against malaria parasites or other pathogens.

U2 - 10.1186/s12936-022-04361-w

DO - 10.1186/s12936-022-04361-w

M3 - Journal article

C2 - 36447200

VL - 21

SP - 356

JO - Malaria Journal

JF - Malaria Journal

SN - 1475-2875

ER -

ID: 327346345