Natriuretic peptides and cerebral hemodynamics
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Natriuretic peptides and cerebral hemodynamics. / Guo, Song; Barringer, Filippa; Zois, Nora Elisabeth; Goetze, Jens P; Ashina, Messoud.
I: Regulatory Peptides, Bind 192-193, 2014, s. 15-23.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Natriuretic peptides and cerebral hemodynamics
AU - Guo, Song
AU - Barringer, Filippa
AU - Zois, Nora Elisabeth
AU - Goetze, Jens P
AU - Ashina, Messoud
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Natriuretic peptides have emerged as important diagnostic and prognostic tools for cardiovascular disease. Plasma measurement of the bioactive peptides as well as precursor-derived fragments is a sensitive tool in assessing heart failure. In heart failure, the peptides are used as treatment in decompensated disease. In contrast, their biological effects on the cerebral hemodynamics are poorly understood. In this mini-review, we summarize the hemodynamic effects of the natriuretic peptides with a focus on the cerebral hemodynamics. In addition, we will discuss its potential implications in diseases where alteration of the cerebral hemodynamics plays a role such as migraine and acute brain injury including stroke. We conclude that a possible role of the peptides is feasible as evaluated from animal and in vitro studies, but more research is needed in humans to determine the precise response on cerebral vessels.
AB - Natriuretic peptides have emerged as important diagnostic and prognostic tools for cardiovascular disease. Plasma measurement of the bioactive peptides as well as precursor-derived fragments is a sensitive tool in assessing heart failure. In heart failure, the peptides are used as treatment in decompensated disease. In contrast, their biological effects on the cerebral hemodynamics are poorly understood. In this mini-review, we summarize the hemodynamic effects of the natriuretic peptides with a focus on the cerebral hemodynamics. In addition, we will discuss its potential implications in diseases where alteration of the cerebral hemodynamics plays a role such as migraine and acute brain injury including stroke. We conclude that a possible role of the peptides is feasible as evaluated from animal and in vitro studies, but more research is needed in humans to determine the precise response on cerebral vessels.
U2 - 10.1016/j.regpep.2014.07.003
DO - 10.1016/j.regpep.2014.07.003
M3 - Review
C2 - 25107278
VL - 192-193
SP - 15
EP - 23
JO - Regulatory Peptides
JF - Regulatory Peptides
SN - 0167-0115
ER -
ID: 137630240