Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography

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Standard

Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography. / Byrne, Christina; Jensen, Tonny; Hjortkjær, Henrik Øder; Mogensen, Ulrik Madvig; Kühl, Jørgen Tobias; Fuchs, Andreas; Hilsted, Jannik; Nordestgaard, Børge G; Køber, Lars; Kofoed, K F.

I: Diabetes Research and Clinical Practice, Bind 107, Nr. 1, 01.2015, s. 15-22.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Byrne, C, Jensen, T, Hjortkjær, HØ, Mogensen, UM, Kühl, JT, Fuchs, A, Hilsted, J, Nordestgaard, BG, Køber, L & Kofoed, KF 2015, 'Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography', Diabetes Research and Clinical Practice, bind 107, nr. 1, s. 15-22. https://doi.org/10.1016/j.diabres.2014.10.011

APA

Byrne, C., Jensen, T., Hjortkjær, H. Ø., Mogensen, U. M., Kühl, J. T., Fuchs, A., Hilsted, J., Nordestgaard, B. G., Køber, L., & Kofoed, K. F. (2015). Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography. Diabetes Research and Clinical Practice, 107(1), 15-22. https://doi.org/10.1016/j.diabres.2014.10.011

Vancouver

Byrne C, Jensen T, Hjortkjær HØ, Mogensen UM, Kühl JT, Fuchs A o.a. Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography. Diabetes Research and Clinical Practice. 2015 jan.;107(1):15-22. https://doi.org/10.1016/j.diabres.2014.10.011

Author

Byrne, Christina ; Jensen, Tonny ; Hjortkjær, Henrik Øder ; Mogensen, Ulrik Madvig ; Kühl, Jørgen Tobias ; Fuchs, Andreas ; Hilsted, Jannik ; Nordestgaard, Børge G ; Køber, Lars ; Kofoed, K F. / Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography. I: Diabetes Research and Clinical Practice. 2015 ; Bind 107, Nr. 1. s. 15-22.

Bibtex

@article{7016c94081254cef990f56e0c5986e31,

title = "Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography",

abstract = "AIM: Type 1 diabetes mellitus (T1DM) is associated with an increased risk of ischemic heart disease (IHD). The relative contribution of structural and functional abnormalities of the coronary circulation determining clinically manifested IHD remains unknown. The aim of this study was to assess potential differences in myocardial perfusion at rest and coronary atherosclerosis between asymptomatic T1DM patients and healthy controls.METHODS: Left ventricular (LV) myocardial perfusion at rest measured as LV myocardial Attenuation Density/LV blood pool Attenuation Density (MyoAD-ratio) and coronary artery atherosclerosis were evaluated with 320-multidetector computed tomography angiography in 57 asymptomatic T1DM patients and 114 sex and age matched controls.RESULTS: In both groups median age was 53 years (p5,p95: 42,67) and 59.6% were men. Median duration of diabetes in the T1DM group was 35 years (p5,p95: 17,49). Median coronary calcium score was higher in T1DM patients (51 vs. 2, p=0.037) compared with controls. However, a similar frequency of >50% stenosis in one or more coronary arteries was found in T1DM patients and controls (18% vs. 14%, p=0.49). LV myocardial perfusion at rest (MyoAD-ratio) was 18% higher in T1DM patients than controls (0.13 vs. 0.11, p<0.0001). This difference was noted throughout all the LV myocardial segments. In a multiple regression analysis including diabetes, sex, age, cardiovascular risk factors, heart rate, calcium score and coronary stenosis >50%, MyoAD-ratio remained significantly higher in T1DM patients (p=0.0001).CONCLUSIONS: LV myocardial perfusion at rest is higher in T1DM patients compared with controls independent of coronary atherosclerosis and cardiovascular risk factors.",

keywords = "Adult, Aged, Case-Control Studies, Diabetes Mellitus, Type 1, Female, Humans, Male, Middle Aged, Myocardial Ischemia, Risk Factors, Tomography, X-Ray Computed",

author = "Christina Byrne and Tonny Jensen and Hjortkj{\ae}r, {Henrik {\O}der} and Mogensen, {Ulrik Madvig} and K{\"u}hl, {J{\o}rgen Tobias} and Andreas Fuchs and Jannik Hilsted and Nordestgaard, {B{\o}rge G} and Lars K{\o}ber and Kofoed, {K F}",

year = "2015",

month = jan,

doi = "10.1016/j.diabres.2014.10.011",

language = "English",

volume = "107",

pages = "15--22",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

RIS

TY - JOUR

T1 - Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography

AU - Byrne, Christina

AU - Jensen, Tonny

AU - Hjortkjær, Henrik Øder

AU - Mogensen, Ulrik Madvig

AU - Kühl, Jørgen Tobias

AU - Fuchs, Andreas

AU - Hilsted, Jannik

AU - Nordestgaard, Børge G

AU - Køber, Lars

AU - Kofoed, K F

PY - 2015/1

Y1 - 2015/1

N2 - AIM: Type 1 diabetes mellitus (T1DM) is associated with an increased risk of ischemic heart disease (IHD). The relative contribution of structural and functional abnormalities of the coronary circulation determining clinically manifested IHD remains unknown. The aim of this study was to assess potential differences in myocardial perfusion at rest and coronary atherosclerosis between asymptomatic T1DM patients and healthy controls.METHODS: Left ventricular (LV) myocardial perfusion at rest measured as LV myocardial Attenuation Density/LV blood pool Attenuation Density (MyoAD-ratio) and coronary artery atherosclerosis were evaluated with 320-multidetector computed tomography angiography in 57 asymptomatic T1DM patients and 114 sex and age matched controls.RESULTS: In both groups median age was 53 years (p5,p95: 42,67) and 59.6% were men. Median duration of diabetes in the T1DM group was 35 years (p5,p95: 17,49). Median coronary calcium score was higher in T1DM patients (51 vs. 2, p=0.037) compared with controls. However, a similar frequency of >50% stenosis in one or more coronary arteries was found in T1DM patients and controls (18% vs. 14%, p=0.49). LV myocardial perfusion at rest (MyoAD-ratio) was 18% higher in T1DM patients than controls (0.13 vs. 0.11, p<0.0001). This difference was noted throughout all the LV myocardial segments. In a multiple regression analysis including diabetes, sex, age, cardiovascular risk factors, heart rate, calcium score and coronary stenosis >50%, MyoAD-ratio remained significantly higher in T1DM patients (p=0.0001).CONCLUSIONS: LV myocardial perfusion at rest is higher in T1DM patients compared with controls independent of coronary atherosclerosis and cardiovascular risk factors.

AB - AIM: Type 1 diabetes mellitus (T1DM) is associated with an increased risk of ischemic heart disease (IHD). The relative contribution of structural and functional abnormalities of the coronary circulation determining clinically manifested IHD remains unknown. The aim of this study was to assess potential differences in myocardial perfusion at rest and coronary atherosclerosis between asymptomatic T1DM patients and healthy controls.METHODS: Left ventricular (LV) myocardial perfusion at rest measured as LV myocardial Attenuation Density/LV blood pool Attenuation Density (MyoAD-ratio) and coronary artery atherosclerosis were evaluated with 320-multidetector computed tomography angiography in 57 asymptomatic T1DM patients and 114 sex and age matched controls.RESULTS: In both groups median age was 53 years (p5,p95: 42,67) and 59.6% were men. Median duration of diabetes in the T1DM group was 35 years (p5,p95: 17,49). Median coronary calcium score was higher in T1DM patients (51 vs. 2, p=0.037) compared with controls. However, a similar frequency of >50% stenosis in one or more coronary arteries was found in T1DM patients and controls (18% vs. 14%, p=0.49). LV myocardial perfusion at rest (MyoAD-ratio) was 18% higher in T1DM patients than controls (0.13 vs. 0.11, p<0.0001). This difference was noted throughout all the LV myocardial segments. In a multiple regression analysis including diabetes, sex, age, cardiovascular risk factors, heart rate, calcium score and coronary stenosis >50%, MyoAD-ratio remained significantly higher in T1DM patients (p=0.0001).CONCLUSIONS: LV myocardial perfusion at rest is higher in T1DM patients compared with controls independent of coronary atherosclerosis and cardiovascular risk factors.

KW - Adult

KW - Aged

KW - Case-Control Studies

KW - Diabetes Mellitus, Type 1

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Ischemia

KW - Risk Factors

KW - Tomography, X-Ray Computed

U2 - 10.1016/j.diabres.2014.10.011

DO - 10.1016/j.diabres.2014.10.011

M3 - Journal article

C2 - 25467625

VL - 107

SP - 15

EP - 22

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 1

ER -

ID: 161582211