Mucociliary and cough clearance as a biomarker for therapeutic development
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Mucociliary and cough clearance as a biomarker for therapeutic development. / Bennett, William D; Daviskas, Evangelia; Hasani, Amir; Mortensen, Jann; Fleming, John; Scheuch, Gerhard.
I: Journal of Aerosol Medicine and Pulmonary Drug Delivery, Bind 23, Nr. 5, 01.10.2010, s. 261-72.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mucociliary and cough clearance as a biomarker for therapeutic development
AU - Bennett, William D
AU - Daviskas, Evangelia
AU - Hasani, Amir
AU - Mortensen, Jann
AU - Fleming, John
AU - Scheuch, Gerhard
PY - 2010/10/1
Y1 - 2010/10/1
N2 - A workshop/symposium on “Mucociliary and Cough Clearance (MCC/CC) as a Biomarker for Therapeutic Development” was held on October 21–22, 2008, in Research Triangle Park, NC, to discuss the methods for measurement of MCC/CC and how they may be optimized for assessing new therapies designed to improve clearance of airway secretions from the lungs. The utility of MCC/CC as a biomarker for disease progression and therapeutic intervention is gaining increased recognition as a valuable tool in the clinical research community. A number of investigators currently active in using MCC/CC for diagnostic or therapeutic evaluation presented details of their methodologies. Attendees participating in the workshop discussions included those interested in the physiology of MCC/CC, some of who use in vitro or animal methods for its study, pharmaceutical companies developing muco-active therapies, and many who were interested in establishing the methods in their own clinical laboratory. This review article summarizes the presentations for the in vivo human MCC/CC methods and the discussions both at and subsequent to the workshop between the authors to move forward on a number of questions raised at the workshop.
AB - A workshop/symposium on “Mucociliary and Cough Clearance (MCC/CC) as a Biomarker for Therapeutic Development” was held on October 21–22, 2008, in Research Triangle Park, NC, to discuss the methods for measurement of MCC/CC and how they may be optimized for assessing new therapies designed to improve clearance of airway secretions from the lungs. The utility of MCC/CC as a biomarker for disease progression and therapeutic intervention is gaining increased recognition as a valuable tool in the clinical research community. A number of investigators currently active in using MCC/CC for diagnostic or therapeutic evaluation presented details of their methodologies. Attendees participating in the workshop discussions included those interested in the physiology of MCC/CC, some of who use in vitro or animal methods for its study, pharmaceutical companies developing muco-active therapies, and many who were interested in establishing the methods in their own clinical laboratory. This review article summarizes the presentations for the in vivo human MCC/CC methods and the discussions both at and subsequent to the workshop between the authors to move forward on a number of questions raised at the workshop.
U2 - http://dx.doi.org/10.1089/jamp.2010.0823
DO - http://dx.doi.org/10.1089/jamp.2010.0823
M3 - Journal article
VL - 23
SP - 261
EP - 272
JO - Journal of Aerosol Medicine and Pulmonary Drug Delivery
JF - Journal of Aerosol Medicine and Pulmonary Drug Delivery
SN - 1941-2711
IS - 5
ER -
ID: 34092691