Mortality in Patients with Central Retinal Vein Occlusion
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Mortality in Patients with Central Retinal Vein Occlusion. / Bertelsen, Mette; Linneberg, Allan; Christoffersen, Nynne; Vorum, Henrik; Gade, Else; Larsen, Michael.
I: Ophthalmology, Bind 121, Nr. 3, 03.2014, s. 637-642.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mortality in Patients with Central Retinal Vein Occlusion
AU - Bertelsen, Mette
AU - Linneberg, Allan
AU - Christoffersen, Nynne
AU - Vorum, Henrik
AU - Gade, Else
AU - Larsen, Michael
N1 - Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
PY - 2014/3
Y1 - 2014/3
N2 - PURPOSE: To assess mortality in patients with central retinal vein occlusion (CRVO).DESIGN: Registry-based cohort study.PARTICIPANTS AND CONTROLS: Four hundred thirty-nine photographically verified CRVO patients and a control cohort of 2195 unexposed subjects matched by age and gender and alive on the date CRVO was diagnosed in the corresponding case.METHODS: Data from nationwide registries were used to compare mortality rates in CRVO patients with a control cohort over a mean follow-up of 5.1 years for cases and of 5.7 years for controls.MAIN OUTCOME MEASURES: Hazard ratios (HRs) obtained by Cox regression and standardized mortality ratios (SMRs) stratified by age and gender served as measures of relative mortality risk.RESULTS: Mortality was higher in patients with CRVO (HR, 1.45; 95% confidence interval [CI], 1.19-1.76) than in the control cohort, adjusted for age, gender, and time of diagnosis. Mortality was comparable between the 2 groups (HR, 1.19; 95% CI, 0.96-1.46) when adjusting for overall occurrence of cardiovascular disease and diabetes. Subgroup analysis found that the age-stratified mortality rate was increased significantly in the total group of men (SMR, 1.27; 95% CI, 1.03-1.56) and in women 60 to 69 years of age (SMR, 1.94; 95% CI, 1.22-3.08).CONCLUSIONS: Central retinal vein occlusion was associated with an overall increase in mortality compared with controls that was attributed statistically to cardiovascular disorders and diabetes. We recommend treatment of hypertension and diabetes, if present, and referral of patients found to have CRVO who are not already being treated by a primary care physician.
AB - PURPOSE: To assess mortality in patients with central retinal vein occlusion (CRVO).DESIGN: Registry-based cohort study.PARTICIPANTS AND CONTROLS: Four hundred thirty-nine photographically verified CRVO patients and a control cohort of 2195 unexposed subjects matched by age and gender and alive on the date CRVO was diagnosed in the corresponding case.METHODS: Data from nationwide registries were used to compare mortality rates in CRVO patients with a control cohort over a mean follow-up of 5.1 years for cases and of 5.7 years for controls.MAIN OUTCOME MEASURES: Hazard ratios (HRs) obtained by Cox regression and standardized mortality ratios (SMRs) stratified by age and gender served as measures of relative mortality risk.RESULTS: Mortality was higher in patients with CRVO (HR, 1.45; 95% confidence interval [CI], 1.19-1.76) than in the control cohort, adjusted for age, gender, and time of diagnosis. Mortality was comparable between the 2 groups (HR, 1.19; 95% CI, 0.96-1.46) when adjusting for overall occurrence of cardiovascular disease and diabetes. Subgroup analysis found that the age-stratified mortality rate was increased significantly in the total group of men (SMR, 1.27; 95% CI, 1.03-1.56) and in women 60 to 69 years of age (SMR, 1.94; 95% CI, 1.22-3.08).CONCLUSIONS: Central retinal vein occlusion was associated with an overall increase in mortality compared with controls that was attributed statistically to cardiovascular disorders and diabetes. We recommend treatment of hypertension and diabetes, if present, and referral of patients found to have CRVO who are not already being treated by a primary care physician.
KW - Age Distribution
KW - Aged
KW - Aged, 80 and over
KW - Cohort Studies
KW - Denmark
KW - Female
KW - Fluorescein Angiography
KW - Humans
KW - Male
KW - Middle Aged
KW - Photography
KW - Proportional Hazards Models
KW - Registries
KW - Retinal Vein Occlusion
KW - Risk Factors
KW - Sex Distribution
U2 - 10.1016/j.ophtha.2013.07.025
DO - 10.1016/j.ophtha.2013.07.025
M3 - Journal article
C2 - 24053999
VL - 121
SP - 637
EP - 642
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 3
ER -
ID: 138547366