Morbidity in early Parkinson's disease and prior to diagnosis
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Morbidity in early Parkinson's disease and prior to diagnosis. / Frandsen, Rune; Kjellberg, Jakob; Ibsen, Rikke; Jennum, Poul.
I: Brain and Behavior, Bind 4, Nr. 3, 2014, s. 446-452.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Morbidity in early Parkinson's disease and prior to diagnosis
AU - Frandsen, Rune
AU - Kjellberg, Jakob
AU - Ibsen, Rikke
AU - Jennum, Poul
PY - 2014
Y1 - 2014
N2 - BACKGROUND: Nonmotor symptoms are probably present prior to, early on, and following, a diagnosis of Parkinson's disease. Nonmotor symptoms may hold important information about the progression of Parkinson's disease.OBJECTIVE: To evaluated the total early and prediagnostic morbidities in the 3 years before a hospital contact leading to a diagnosis of Parkinson's disease.METHODS: Retrospective morbidity data from Danish National Patient Registry records (1997-2007) of 10,490 adult patients with a secondary care diagnosis of Parkinson's disease were compared with 42,505 control cases.RESULTS: Parkinson's disease was associated with significantly higher morbidity rates associated with conditions in the following categories: mental and psychiatric, nervous system, gastrointestinal, musculoskeletal system and connective tissue, genitourinary, abnormal clinical and laboratory findings, injury, poisoning and certain other external causes, and other factors influencing health status and contact with health services. It was negatively associated with neoplasm, cardiovascular, and respiratory diseases.CONCLUSIONS: Patients with a diagnosis of Parkinson's disease present significant differences in morbidities early on, following, and prior to, their diagnosis, compared with healthy controls.
AB - BACKGROUND: Nonmotor symptoms are probably present prior to, early on, and following, a diagnosis of Parkinson's disease. Nonmotor symptoms may hold important information about the progression of Parkinson's disease.OBJECTIVE: To evaluated the total early and prediagnostic morbidities in the 3 years before a hospital contact leading to a diagnosis of Parkinson's disease.METHODS: Retrospective morbidity data from Danish National Patient Registry records (1997-2007) of 10,490 adult patients with a secondary care diagnosis of Parkinson's disease were compared with 42,505 control cases.RESULTS: Parkinson's disease was associated with significantly higher morbidity rates associated with conditions in the following categories: mental and psychiatric, nervous system, gastrointestinal, musculoskeletal system and connective tissue, genitourinary, abnormal clinical and laboratory findings, injury, poisoning and certain other external causes, and other factors influencing health status and contact with health services. It was negatively associated with neoplasm, cardiovascular, and respiratory diseases.CONCLUSIONS: Patients with a diagnosis of Parkinson's disease present significant differences in morbidities early on, following, and prior to, their diagnosis, compared with healthy controls.
U2 - 10.1002/brb3.228
DO - 10.1002/brb3.228
M3 - Journal article
C2 - 24944873
VL - 4
SP - 446
EP - 452
JO - Brain and Behavior
JF - Brain and Behavior
SN - 2157-9032
IS - 3
ER -
ID: 138179655