Mitogen activated protein kinases: a role in inflammatory bowel disease?
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Mitogen activated protein kinases: a role in inflammatory bowel disease? / Broom, O J; Widjaya, B; Troelsen, J; Olsen, Jørgen; Nielsen, O H.
I: Clinical and Experimental Immunology, Bind 158, Nr. 3, 2009, s. 272-80.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mitogen activated protein kinases: a role in inflammatory bowel disease?
AU - Broom, O J
AU - Widjaya, B
AU - Troelsen, J
AU - Olsen, Jørgen
AU - Nielsen, O H
PY - 2009
Y1 - 2009
N2 - Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.
AB - Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.
U2 - 10.1111/j.1365-2249.2009.04033.x
DO - 10.1111/j.1365-2249.2009.04033.x
M3 - Journal article
C2 - 19793335
VL - 158
SP - 272
EP - 280
JO - Clinical and Experimental Immunology, Supplement
JF - Clinical and Experimental Immunology, Supplement
SN - 0964-2536
IS - 3
ER -
ID: 16863329