Microchimerism and survival after breast and colon cancer diagnosis
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Microchimerism and survival after breast and colon cancer diagnosis. / Kamper-Jørgensen, Mads.
I: Chimerism, Bind 3, Nr. 3, 2012, s. 72-3.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Microchimerism and survival after breast and colon cancer diagnosis
AU - Kamper-Jørgensen, Mads
PY - 2012
Y1 - 2012
N2 - Recently, we reported microchimerism to be oppositely associated with maternal breast and colon cancer. In women with a blood test positive for male microchimerism the risk of breast cancer development was reduced to one third, whereas the risk of colon cancer was elevated 4-fold. In this article addendum, I report the survival of cases in the original study after being diagnosed with cancer. Despite small numbers, the analysis suggests that microchimerism may be positively associated with survival after breast and maybe colon cancer diagnosis. Despite the findings on colon cancer in our original report, I speculate whether microchimerism could have a general beneficial role in cancer, which in some sites may not be evident because an allogeneic maternal immune reaction hastens cancer development.
AB - Recently, we reported microchimerism to be oppositely associated with maternal breast and colon cancer. In women with a blood test positive for male microchimerism the risk of breast cancer development was reduced to one third, whereas the risk of colon cancer was elevated 4-fold. In this article addendum, I report the survival of cases in the original study after being diagnosed with cancer. Despite small numbers, the analysis suggests that microchimerism may be positively associated with survival after breast and maybe colon cancer diagnosis. Despite the findings on colon cancer in our original report, I speculate whether microchimerism could have a general beneficial role in cancer, which in some sites may not be evident because an allogeneic maternal immune reaction hastens cancer development.
U2 - 10.4161/chim.22770
DO - 10.4161/chim.22770
M3 - Journal article
C2 - 23128043
VL - 3
SP - 72
EP - 73
JO - Chimerism
JF - Chimerism
SN - 1938-1956
IS - 3
ER -
ID: 44257798