Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. / Van Dijck, Patrick; Sjollema, Jelmer; Cammue, Bruno P; Lagrou, Katrien; Berman, Judith; d'Enfert, Christophe; Andes, David R; Arendrup, Maiken C.; Brakhage, Axel A; Calderone, Richard; Cantón, Emilia; Coenye, Tom; Cos, Paul; Cowen, Leah E; Edgerton, Mira; Espinel-Ingroff, Ana; Filler, Scott G; Ghannoum, Mahmoud; Gow, Neil A R; Haas, Hubertus; Jabra-Rizk, Mary Ann; Johnson, Elizabeth M; Lockhart, Shawn R; Lopez-Ribot, Jose L; Maertens, Johan; Munro, Carol A; Nett, Jeniel E; Nobile, Clarissa J; Pfaller, Michael A; Ramage, Gordon; Sanglard, Dominique; Sanguinetti, Maurizio; Spriet, Isabel; Verweij, Paul E; Warris, Adilia; Wauters, Joost; Yeaman, Michael R; Zaat, Sebastian A J; Thevissen, Karin.
I: Microbial Cell Factories, Bind 5, Nr. 7, 2018, s. 300-326.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms
AU - Van Dijck, Patrick
AU - Sjollema, Jelmer
AU - Cammue, Bruno P
AU - Lagrou, Katrien
AU - Berman, Judith
AU - d'Enfert, Christophe
AU - Andes, David R
AU - Arendrup, Maiken C.
AU - Brakhage, Axel A
AU - Calderone, Richard
AU - Cantón, Emilia
AU - Coenye, Tom
AU - Cos, Paul
AU - Cowen, Leah E
AU - Edgerton, Mira
AU - Espinel-Ingroff, Ana
AU - Filler, Scott G
AU - Ghannoum, Mahmoud
AU - Gow, Neil A R
AU - Haas, Hubertus
AU - Jabra-Rizk, Mary Ann
AU - Johnson, Elizabeth M
AU - Lockhart, Shawn R
AU - Lopez-Ribot, Jose L
AU - Maertens, Johan
AU - Munro, Carol A
AU - Nett, Jeniel E
AU - Nobile, Clarissa J
AU - Pfaller, Michael A
AU - Ramage, Gordon
AU - Sanglard, Dominique
AU - Sanguinetti, Maurizio
AU - Spriet, Isabel
AU - Verweij, Paul E
AU - Warris, Adilia
AU - Wauters, Joost
AU - Yeaman, Michael R
AU - Zaat, Sebastian A J
AU - Thevissen, Karin
PY - 2018
Y1 - 2018
N2 - Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.
AB - Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.
U2 - 10.15698/mic2018.07.638
DO - 10.15698/mic2018.07.638
M3 - Review
C2 - 29992128
VL - 5
SP - 300
EP - 326
JO - Microbial Cell
JF - Microbial Cell
SN - 1475-2859
IS - 7
ER -
ID: 218710269