Metabonomic investigation of human Schistosoma mansoni infection
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Metabonomic investigation of human Schistosoma mansoni infection. / Balog, Crina I.A.; Meissner, Axel; Göraler, Sibel; Bladergroen, Marco R.; Vennervald, Birgitte J; Mayboroda, Oleg A. ; Deelder, André M.
I: Molecular BioSystems, Bind 7, Nr. 5, 2011, s. 1473-80.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Metabonomic investigation of human Schistosoma mansoni infection
AU - Balog, Crina I.A.
AU - Meissner, Axel
AU - Göraler, Sibel
AU - Bladergroen, Marco R.
AU - Vennervald, Birgitte J
AU - Mayboroda, Oleg A.
AU - Deelder, André M.
PY - 2011
Y1 - 2011
N2 - Schistosomiasis is a parasitic infection that is endemic in many developing countries in the tropics and subtropics afflicting more than 207 million people primarily in rural areas. After malaria, it is the second most important parasitic infection in terms of socio-economic and public health. Investigation of the host-parasite interaction at the molecular level and identification of biomarkers of infection and infection-related morbidity would be of value for improved strategies for treatment and morbidity control. To this end, we conducted a nuclear magnetic resonance (NMR) based metabonomics study involving a well-characterized cohort of 447 individuals from a rural area in Uganda near Lake Victoria with a high prevalence of Schistosoma mansoni, a species predominantly occurring in Africa including Madagascar and parts of South America. Cohort samples were collected from individuals at five time-points, before and after (one or two times) chemotherapy with praziquantel (PZQ). Using supervised multivariate statistical analysis of the recorded one-dimensional (1D) NMR spectra, we were able to discriminate infected from uninfected individuals in two age groups (children and adults) based on differences in their urinary profiles. The potential molecular markers of S. mansoni infection were found to be primarily linked to changes in gut microflora, energy metabolism and liver function. These findings are in agreement with data from earlier studies on S. mansoni infection in experimental animals and thus provide corroborating evidence for the existence of metabolic response specific for this infection.
AB - Schistosomiasis is a parasitic infection that is endemic in many developing countries in the tropics and subtropics afflicting more than 207 million people primarily in rural areas. After malaria, it is the second most important parasitic infection in terms of socio-economic and public health. Investigation of the host-parasite interaction at the molecular level and identification of biomarkers of infection and infection-related morbidity would be of value for improved strategies for treatment and morbidity control. To this end, we conducted a nuclear magnetic resonance (NMR) based metabonomics study involving a well-characterized cohort of 447 individuals from a rural area in Uganda near Lake Victoria with a high prevalence of Schistosoma mansoni, a species predominantly occurring in Africa including Madagascar and parts of South America. Cohort samples were collected from individuals at five time-points, before and after (one or two times) chemotherapy with praziquantel (PZQ). Using supervised multivariate statistical analysis of the recorded one-dimensional (1D) NMR spectra, we were able to discriminate infected from uninfected individuals in two age groups (children and adults) based on differences in their urinary profiles. The potential molecular markers of S. mansoni infection were found to be primarily linked to changes in gut microflora, energy metabolism and liver function. These findings are in agreement with data from earlier studies on S. mansoni infection in experimental animals and thus provide corroborating evidence for the existence of metabolic response specific for this infection.
KW - Adolescent
KW - Adult
KW - Aged
KW - Animals
KW - Anthelmintics
KW - Biological Markers
KW - Child
KW - Cohort Studies
KW - Feces
KW - Female
KW - Host-Parasite Interactions
KW - Humans
KW - Magnetic Resonance Spectroscopy
KW - Male
KW - Metabolomics
KW - Middle Aged
KW - Multivariate Analysis
KW - Praziquantel
KW - Schistosoma mansoni
KW - Schistosomiasis mansoni
KW - Time Factors
KW - Uganda
KW - Young Adult
U2 - 10.1039/c0mb00262c
DO - 10.1039/c0mb00262c
M3 - Journal article
C2 - 21336380
VL - 7
SP - 1473
EP - 1480
JO - Molecular BioSystems
JF - Molecular BioSystems
SN - 1742-206X
IS - 5
ER -
ID: 34499123