Mechanisms and factors that influence high frequency retroviral recombination

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Standard

Mechanisms and factors that influence high frequency retroviral recombination. / Delviks-Frankenberry, Krista; Galli, Andrea; Nikolaitchik, Olga; Mens, Helene; Pathak, Vinay K.; Hu, Wei Shau.

I: Viruses, Bind 3, Nr. 9, 09.2011, s. 1650-1680.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Delviks-Frankenberry, K, Galli, A, Nikolaitchik, O, Mens, H, Pathak, VK & Hu, WS 2011, 'Mechanisms and factors that influence high frequency retroviral recombination', Viruses, bind 3, nr. 9, s. 1650-1680. https://doi.org/10.3390/v3091650

APA

Delviks-Frankenberry, K., Galli, A., Nikolaitchik, O., Mens, H., Pathak, V. K., & Hu, W. S. (2011). Mechanisms and factors that influence high frequency retroviral recombination. Viruses, 3(9), 1650-1680. https://doi.org/10.3390/v3091650

Vancouver

Delviks-Frankenberry K, Galli A, Nikolaitchik O, Mens H, Pathak VK, Hu WS. Mechanisms and factors that influence high frequency retroviral recombination. Viruses. 2011 sep.;3(9):1650-1680. https://doi.org/10.3390/v3091650

Author

Delviks-Frankenberry, Krista ; Galli, Andrea ; Nikolaitchik, Olga ; Mens, Helene ; Pathak, Vinay K. ; Hu, Wei Shau. / Mechanisms and factors that influence high frequency retroviral recombination. I: Viruses. 2011 ; Bind 3, Nr. 9. s. 1650-1680.

Bibtex

@article{05e5b1a3d4674181a8a244de26e92ed0,

title = "Mechanisms and factors that influence high frequency retroviral recombination",

abstract = "With constantly changing environmental selection pressures, retroviruses rely upon recombination to reassort polymorphisms in their genomes and increase genetic diversity, which improves the chances for the survival of their population. Recombination occurs during DNA synthesis, whereby reverse transcriptase undergoes template switching events between the two copackaged RNAs, resulting in a viral recombinant with portions of the genetic information from each parental RNA. This review summarizes our current understanding of the factors and mechanisms influencing retroviral recombination, fidelity of the recombination process, and evaluates the subsequent viral diversity and fitness of the progeny recombinant. Specifically, the high mutation rates and high recombination frequencies of HIV-1 will be analyzed for their roles in influencing HIV-1 global diversity, as well as HIV-1 diagnosis, drug treatment, and vaccine development.",

keywords = "HIV-1, Recombination, Retrovirus",

author = "Krista Delviks-Frankenberry and Andrea Galli and Olga Nikolaitchik and Helene Mens and Pathak, {Vinay K.} and Hu, {Wei Shau}",

year = "2011",

month = sep,

doi = "10.3390/v3091650",

language = "English",

volume = "3",

pages = "1650--1680",

journal = "Viruses",

issn = "1999-4915",

publisher = "M D P I AG",

number = "9",

}

RIS

TY - JOUR

T1 - Mechanisms and factors that influence high frequency retroviral recombination

AU - Delviks-Frankenberry, Krista

AU - Galli, Andrea

AU - Nikolaitchik, Olga

AU - Mens, Helene

AU - Pathak, Vinay K.

AU - Hu, Wei Shau

PY - 2011/9

Y1 - 2011/9

N2 - With constantly changing environmental selection pressures, retroviruses rely upon recombination to reassort polymorphisms in their genomes and increase genetic diversity, which improves the chances for the survival of their population. Recombination occurs during DNA synthesis, whereby reverse transcriptase undergoes template switching events between the two copackaged RNAs, resulting in a viral recombinant with portions of the genetic information from each parental RNA. This review summarizes our current understanding of the factors and mechanisms influencing retroviral recombination, fidelity of the recombination process, and evaluates the subsequent viral diversity and fitness of the progeny recombinant. Specifically, the high mutation rates and high recombination frequencies of HIV-1 will be analyzed for their roles in influencing HIV-1 global diversity, as well as HIV-1 diagnosis, drug treatment, and vaccine development.

AB - With constantly changing environmental selection pressures, retroviruses rely upon recombination to reassort polymorphisms in their genomes and increase genetic diversity, which improves the chances for the survival of their population. Recombination occurs during DNA synthesis, whereby reverse transcriptase undergoes template switching events between the two copackaged RNAs, resulting in a viral recombinant with portions of the genetic information from each parental RNA. This review summarizes our current understanding of the factors and mechanisms influencing retroviral recombination, fidelity of the recombination process, and evaluates the subsequent viral diversity and fitness of the progeny recombinant. Specifically, the high mutation rates and high recombination frequencies of HIV-1 will be analyzed for their roles in influencing HIV-1 global diversity, as well as HIV-1 diagnosis, drug treatment, and vaccine development.

KW - HIV-1

KW - Recombination

KW - Retrovirus

UR - http://www.scopus.com/inward/record.url?scp=80053313880&partnerID=8YFLogxK

U2 - 10.3390/v3091650

DO - 10.3390/v3091650

M3 - Journal article

C2 - 21994801

AN - SCOPUS:80053313880

VL - 3

SP - 1650

EP - 1680

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 9

ER -

ID: 379291556