Mechanisms and consequences of oxidative damage to extracellular matrix
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Mechanisms and consequences of oxidative damage to extracellular matrix. / Kennett, Eleanor C; Chuang, Christine Y; Degendorfer, Georg; Whitelock, John M; Davies, Michael Jonathan.
I: Biochemical Society Transactions, Bind 39, Nr. 5, 10.2011, s. 1279-87.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mechanisms and consequences of oxidative damage to extracellular matrix
AU - Kennett, Eleanor C
AU - Chuang, Christine Y
AU - Degendorfer, Georg
AU - Whitelock, John M
AU - Davies, Michael Jonathan
PY - 2011/10
Y1 - 2011/10
N2 - Considerable evidence exists for oxidative damage to extracellular materials during multiple human pathologies. Unlike cells, the extracellular compartment of most biological tissues is less well protected against oxidation than intracellular sites in terms of the presence of both antioxidants (low molecular mass and enzymatic) and repair enzymes. The extracellular compartment may therefore be subject to greater oxidative stress, marked alterations in redox balance and an accumulation of damage due to slow turnover and/or poor repair. The nature and consequences of damage to ECM (extracellular matrix) are poorly understood, despite the growing realization that changes in matrix structure not only have structural consequences, but also play a key role in the regulation of cellular adhesion, proliferation, migration and cell signalling. The ECM also plays a key role in cytokine and growth factor binding, and matrix modifications would therefore be expected to alter these parameters. In the present study, we review mechanisms of oxidative damage to ECM, resulting changes in matrix structure and how this affects cellular behaviour. The role of such damage in the development and progression of inflammatory diseases is also discussed with particular reference to cardiovascular disease.
AB - Considerable evidence exists for oxidative damage to extracellular materials during multiple human pathologies. Unlike cells, the extracellular compartment of most biological tissues is less well protected against oxidation than intracellular sites in terms of the presence of both antioxidants (low molecular mass and enzymatic) and repair enzymes. The extracellular compartment may therefore be subject to greater oxidative stress, marked alterations in redox balance and an accumulation of damage due to slow turnover and/or poor repair. The nature and consequences of damage to ECM (extracellular matrix) are poorly understood, despite the growing realization that changes in matrix structure not only have structural consequences, but also play a key role in the regulation of cellular adhesion, proliferation, migration and cell signalling. The ECM also plays a key role in cytokine and growth factor binding, and matrix modifications would therefore be expected to alter these parameters. In the present study, we review mechanisms of oxidative damage to ECM, resulting changes in matrix structure and how this affects cellular behaviour. The role of such damage in the development and progression of inflammatory diseases is also discussed with particular reference to cardiovascular disease.
KW - Antioxidants
KW - Cardiovascular Diseases
KW - Disease Progression
KW - Extracellular Matrix
KW - Heparan Sulfate Proteoglycans
KW - Humans
KW - Oxidants
KW - Oxidation-Reduction
KW - Oxidative Stress
KW - Reactive Nitrogen Species
KW - Reactive Oxygen Species
U2 - 10.1042/BST0391279
DO - 10.1042/BST0391279
M3 - Journal article
C2 - 21936802
VL - 39
SP - 1279
EP - 1287
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
SN - 0300-5127
IS - 5
ER -
ID: 129669397