Maternal Intake of Probiotics to Program Offspring Health
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Maternal Intake of Probiotics to Program Offspring Health. / Cuinat, Céline; Stinson, Sara Elizabeth; Ward, Wendy E.; Comelli, Elena M.
I: Current Nutrition Reports, Bind 11, 2022, s. 537–562.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Maternal Intake of Probiotics to Program Offspring Health
AU - Cuinat, Céline
AU - Stinson, Sara Elizabeth
AU - Ward, Wendy E.
AU - Comelli, Elena M.
PY - 2022
Y1 - 2022
N2 - Purpose of Review Probiotics intake may be considered beneficial by prospective and pregnant mothers, but their effects on offspring development are incompletely understood. The purpose of this review was to examine recent pre-clinical and clinical studies to understand how maternal probiotics exposure affects offspring health outcomes.Recent Findings Effects were investigated in the context of supporting offspring growth, intestinal health, and gut microbiota, preventing allergic diseases, supporting neurodevelopment, and preventing metabolic disorders in pre-clinical and clinical studies. Most human studies focused on infancy outcomes, whereas pre-clinical studies also examined outcomes at adolescence and young adulthood. While still understudied, both pre-clinical and clinical studies propose epigenetic modifications as an underlying mechanism. Optimal timing of intervention remains unclear.Summary Administration of selected probiotics to mothers has programming potential for sustaining life-long health of offspring. Administration protocols, specific windows of susceptibility, and individual-specific responses need to be further studied.
AB - Purpose of Review Probiotics intake may be considered beneficial by prospective and pregnant mothers, but their effects on offspring development are incompletely understood. The purpose of this review was to examine recent pre-clinical and clinical studies to understand how maternal probiotics exposure affects offspring health outcomes.Recent Findings Effects were investigated in the context of supporting offspring growth, intestinal health, and gut microbiota, preventing allergic diseases, supporting neurodevelopment, and preventing metabolic disorders in pre-clinical and clinical studies. Most human studies focused on infancy outcomes, whereas pre-clinical studies also examined outcomes at adolescence and young adulthood. While still understudied, both pre-clinical and clinical studies propose epigenetic modifications as an underlying mechanism. Optimal timing of intervention remains unclear.Summary Administration of selected probiotics to mothers has programming potential for sustaining life-long health of offspring. Administration protocols, specific windows of susceptibility, and individual-specific responses need to be further studied.
U2 - 10.1007/s13668-022-00429-w
DO - 10.1007/s13668-022-00429-w
M3 - Journal article
C2 - 35986890
VL - 11
SP - 537
EP - 562
JO - Current Nutrition Reports
JF - Current Nutrition Reports
SN - 2161-3311
ER -
ID: 317005006