Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients
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Homozygous carriage of a 14 base pair (bp) insertion in exon 8 of the HLA-G gene may be associated with low levels of soluble HLA-G and recurrent miscarriage (RM). We investigated the G14bp insertion(ins)/deletion(del) polymorphism in 339 women with unexplained RM and 125 control women. In all patients and patients with secondary RM after a firstborn boy, 19.2% and 23.9%, respectively, were G14bp ins/ins compared with 11.2% of controls (p
Originalsprog | Engelsk |
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Tidsskrift | Human Immunology |
Vol/bind | 73 |
Udgave nummer | 7 |
Sider (fra-til) | 699-705 |
Antal sider | 7 |
ISSN | 0198-8859 |
DOI | |
Status | Udgivet - jul. 2012 |
ID: 47923510