Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
During pregnancy and lactation, subcutaneous white adipocytes in the mouse mammary gland
transdifferentiate reversibly to milk-secreting epithelial cells. In this study, we demonstrate by
transmission electron microscopy that in the post-lactating mammary gland interscapular
multilocular adipocytes found close to the mammary alveoli contain milk protein granules. Use
of the Cre-loxP recombination system allowed showing that the involuting mammary gland of
whey acidic protein-Cre/R26R mice, whose secretory alveolar cells express the lacZ gene during
pregnancy, contains some X-Gal-stained and uncoupling protein 1-positive interscapular
multilocular adipocytes. These data suggest that during mammary gland involution some milk-
secreting epithelial cells in the anterior subcutaneous depot may transdifferentiate to brown
adipocytes, highlighting a hitherto unappreciated feature of mouse adipose organ plasticity
transdifferentiate reversibly to milk-secreting epithelial cells. In this study, we demonstrate by
transmission electron microscopy that in the post-lactating mammary gland interscapular
multilocular adipocytes found close to the mammary alveoli contain milk protein granules. Use
of the Cre-loxP recombination system allowed showing that the involuting mammary gland of
whey acidic protein-Cre/R26R mice, whose secretory alveolar cells express the lacZ gene during
pregnancy, contains some X-Gal-stained and uncoupling protein 1-positive interscapular
multilocular adipocytes. These data suggest that during mammary gland involution some milk-
secreting epithelial cells in the anterior subcutaneous depot may transdifferentiate to brown
adipocytes, highlighting a hitherto unappreciated feature of mouse adipose organ plasticity
Originalsprog | Engelsk |
---|---|
Tidsskrift | Journal of Cellular Physiology |
Vol/bind | 232 |
Udgave nummer | 11 |
Sider (fra-til) | 2923-2928 |
Antal sider | 6 |
ISSN | 0021-9541 |
DOI | |
Status | Udgivet - 2017 |
ID: 183637824