Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial

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Standard

Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial. / Holt, Rune; Yahyavi, Sam Kafai; Wall-Gremstrup, Gustav; Jorsal, Mads Joon; Toft, Frederikke Bay; Jørgensen, Niels; Juul, Anders; Jensen, Martin Blomberg.

I: Fertility and Sterility, Bind 122, Nr. 2, 2024, s. 278-287.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Holt, R, Yahyavi, SK, Wall-Gremstrup, G, Jorsal, MJ, Toft, FB, Jørgensen, N, Juul, A & Jensen, MB 2024, 'Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial', Fertility and Sterility, bind 122, nr. 2, s. 278-287. https://doi.org/10.1016/j.fertnstert.2024.03.018

APA

Holt, R., Yahyavi, S. K., Wall-Gremstrup, G., Jorsal, M. J., Toft, F. B., Jørgensen, N., Juul, A., & Jensen, M. B. (2024). Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial. Fertility and Sterility, 122(2), 278-287. https://doi.org/10.1016/j.fertnstert.2024.03.018

Vancouver

Holt R, Yahyavi SK, Wall-Gremstrup G, Jorsal MJ, Toft FB, Jørgensen N o.a. Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial. Fertility and Sterility. 2024;122(2):278-287. https://doi.org/10.1016/j.fertnstert.2024.03.018

Author

Holt, Rune ; Yahyavi, Sam Kafai ; Wall-Gremstrup, Gustav ; Jorsal, Mads Joon ; Toft, Frederikke Bay ; Jørgensen, Niels ; Juul, Anders ; Jensen, Martin Blomberg. / Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial. I: Fertility and Sterility. 2024 ; Bind 122, Nr. 2. s. 278-287.

Bibtex

@article{858d44d8be8f4fbb8e1038aff5b06dad,

title = "Low-serum antim{\"u}llerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial",

abstract = "Objective: To investigate possible associations between serum antim{\"u}llerian hormone (AMH) concentration and semen quality in infertile men. Studies investigating the associations between serum AMH concentration and semen quality in infertile men have shown conflicting results. Design: Infertile men were included during screening for participation in the First in Treating Male Infertility Study, a double-blinded, placebo-controlled, 1:1, single-center randomized controlled trial. Setting: Not applicable. Patients: At the screening visit, 400 participants produced a semen sample and had their serum analyzed for AMH concentration. Intervention: Not applicable. Main Outcome Measures: Serum AMH concentration and semen quality. Results: All men were stratified according to serum AMH concentrations in quartiles (Q1–Q4). Men in the lowest quartile had a lower sperm concentration (1 × 106/mL) (Q1: 8.0 vs. Q2: 10.4 vs. Q3: 11.0 vs. Q4: 13.0), total sperm count (1 × 106) (Q1: 29.1 vs. Q2: 38.2 vs. Q3: 44.4 vs. Q4: 55.7), sperm motility (%) (Q1: 41 vs. Q2: 57 vs. Q3: 50 vs. Q4: 53), and progressive sperm motility (%) (Q1: 31 vs. Q2: 44 vs. Q3: 35 vs. Q4: 40) compared with the other quartiles. Moreover, men with a sperm concentration <2 million/mL had a lower serum AMH concentration compared with men having 2–16 × 106 /mL and >16 × 106/mL (31 pmol/L vs. 38 pmol/L vs. 43 pmol/L, respectively). In accordance, men with sperm motility <20% had a lower serum AMH concentration compared with men with sperm motility 20%–42%, and >42% (31 pmol/L vs. 43 pmol/L. vs. 39 pmol/L, respectively). Conclusion: This study shows that low serum AMH concentration is associated with poor semen quality in infertile men, which implies that serum AMH concentration may have clinical value during the evaluation of male infertility. Clinical Trial Registration Number: NCT05212337",

keywords = "AMH, male infertility, semen quality",

author = "Rune Holt and Yahyavi, {Sam Kafai} and Gustav Wall-Gremstrup and Jorsal, {Mads Joon} and Toft, {Frederikke Bay} and Niels J{\o}rgensen and Anders Juul and Jensen, {Martin Blomberg}",

note = "Publisher Copyright: {\textcopyright} 2024 American Society for Reproductive Medicine",

year = "2024",

doi = "10.1016/j.fertnstert.2024.03.018",

language = "English",

volume = "122",

pages = "278--287",

journal = "Sexuality, Reproduction and Menopause",

issn = "1546-2501",

publisher = "Elsevier",

number = "2",

}

RIS

TY - JOUR

T1 - Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial

AU - Holt, Rune

AU - Yahyavi, Sam Kafai

AU - Wall-Gremstrup, Gustav

AU - Jorsal, Mads Joon

AU - Toft, Frederikke Bay

AU - Jørgensen, Niels

AU - Juul, Anders

AU - Jensen, Martin Blomberg

PY - 2024

Y1 - 2024

N2 - Objective: To investigate possible associations between serum antimüllerian hormone (AMH) concentration and semen quality in infertile men. Studies investigating the associations between serum AMH concentration and semen quality in infertile men have shown conflicting results. Design: Infertile men were included during screening for participation in the First in Treating Male Infertility Study, a double-blinded, placebo-controlled, 1:1, single-center randomized controlled trial. Setting: Not applicable. Patients: At the screening visit, 400 participants produced a semen sample and had their serum analyzed for AMH concentration. Intervention: Not applicable. Main Outcome Measures: Serum AMH concentration and semen quality. Results: All men were stratified according to serum AMH concentrations in quartiles (Q1–Q4). Men in the lowest quartile had a lower sperm concentration (1 × 106/mL) (Q1: 8.0 vs. Q2: 10.4 vs. Q3: 11.0 vs. Q4: 13.0), total sperm count (1 × 106) (Q1: 29.1 vs. Q2: 38.2 vs. Q3: 44.4 vs. Q4: 55.7), sperm motility (%) (Q1: 41 vs. Q2: 57 vs. Q3: 50 vs. Q4: 53), and progressive sperm motility (%) (Q1: 31 vs. Q2: 44 vs. Q3: 35 vs. Q4: 40) compared with the other quartiles. Moreover, men with a sperm concentration <2 million/mL had a lower serum AMH concentration compared with men having 2–16 × 106 /mL and >16 × 106/mL (31 pmol/L vs. 38 pmol/L vs. 43 pmol/L, respectively). In accordance, men with sperm motility <20% had a lower serum AMH concentration compared with men with sperm motility 20%–42%, and >42% (31 pmol/L vs. 43 pmol/L. vs. 39 pmol/L, respectively). Conclusion: This study shows that low serum AMH concentration is associated with poor semen quality in infertile men, which implies that serum AMH concentration may have clinical value during the evaluation of male infertility. Clinical Trial Registration Number: NCT05212337

AB - Objective: To investigate possible associations between serum antimüllerian hormone (AMH) concentration and semen quality in infertile men. Studies investigating the associations between serum AMH concentration and semen quality in infertile men have shown conflicting results. Design: Infertile men were included during screening for participation in the First in Treating Male Infertility Study, a double-blinded, placebo-controlled, 1:1, single-center randomized controlled trial. Setting: Not applicable. Patients: At the screening visit, 400 participants produced a semen sample and had their serum analyzed for AMH concentration. Intervention: Not applicable. Main Outcome Measures: Serum AMH concentration and semen quality. Results: All men were stratified according to serum AMH concentrations in quartiles (Q1–Q4). Men in the lowest quartile had a lower sperm concentration (1 × 106/mL) (Q1: 8.0 vs. Q2: 10.4 vs. Q3: 11.0 vs. Q4: 13.0), total sperm count (1 × 106) (Q1: 29.1 vs. Q2: 38.2 vs. Q3: 44.4 vs. Q4: 55.7), sperm motility (%) (Q1: 41 vs. Q2: 57 vs. Q3: 50 vs. Q4: 53), and progressive sperm motility (%) (Q1: 31 vs. Q2: 44 vs. Q3: 35 vs. Q4: 40) compared with the other quartiles. Moreover, men with a sperm concentration <2 million/mL had a lower serum AMH concentration compared with men having 2–16 × 106 /mL and >16 × 106/mL (31 pmol/L vs. 38 pmol/L vs. 43 pmol/L, respectively). In accordance, men with sperm motility <20% had a lower serum AMH concentration compared with men with sperm motility 20%–42%, and >42% (31 pmol/L vs. 43 pmol/L. vs. 39 pmol/L, respectively). Conclusion: This study shows that low serum AMH concentration is associated with poor semen quality in infertile men, which implies that serum AMH concentration may have clinical value during the evaluation of male infertility. Clinical Trial Registration Number: NCT05212337

KW - AMH

KW - male infertility

KW - semen quality

U2 - 10.1016/j.fertnstert.2024.03.018

DO - 10.1016/j.fertnstert.2024.03.018

M3 - Journal article

C2 - 38522503

AN - SCOPUS:85190533175

VL - 122

SP - 278

EP - 287

JO - Sexuality, Reproduction and Menopause

JF - Sexuality, Reproduction and Menopause

SN - 1546-2501

IS - 2

ER -

ID: 389509487