Low plasma levels of calcitonin gene-related peptide in persistent post-traumatic headache attributed to mild traumatic brain injury
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Low plasma levels of calcitonin gene-related peptide in persistent post-traumatic headache attributed to mild traumatic brain injury. / Ashina, Håkan; Al-Khazali, Haidar Muhsen; Iljazi, Afrim; Ashina, Sait; Jørgensen, Niklas Rye; Amin, Faisal Mohammad; Ashina, Messoud; Schytz, Henrik Winther.
I: Cephalalgia, Bind 40, Nr. 12, 2020, s. 1276-1282.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Low plasma levels of calcitonin gene-related peptide in persistent post-traumatic headache attributed to mild traumatic brain injury
AU - Ashina, Håkan
AU - Al-Khazali, Haidar Muhsen
AU - Iljazi, Afrim
AU - Ashina, Sait
AU - Jørgensen, Niklas Rye
AU - Amin, Faisal Mohammad
AU - Ashina, Messoud
AU - Schytz, Henrik Winther
PY - 2020
Y1 - 2020
N2 - Objective: To investigate the role of calcitonin gene-related peptide (CGRP) in persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI). Methods: A total of 100 individuals with persistent PTH attributed to mild TBI and 100 age- and gender-matched healthy controls were enrolled between July 2018 and June 2019. Blood was drawn from the antecubital vein and subsequently analyzed using a validated radioimmunoassay for human CGRP. Measurements were performed on coded samples by a board-certified laboratory technician who was blind to clinical information. Results: CGRP plasma levels were lower in subjects with persistent PTH (mean, 75.8 pmol/L; SD, 26.4 pmol/L), compared with age- and gender-matched healthy controls (mean, 88.0 pmol/L; SD, 34.1 pmol/L) (p = 0.04). No correlation was found of CGRP plasma levels with monthly headache days (r = −0.11; p = 0.27), monthly migraine-like days (r = 0.15; p = 0.13), headache quality (r = −0.14; p = 0.15), or a chronic migraine-like headache phenotype (r = −0.02; p = 0.85). Conclusions: CGRP plasma measurements are unlikely a feasible blood-based biomarker of persistent PTH. Future studies should assess whether CGRP plasma measurements can be used to predict development of persistent PTH.
AB - Objective: To investigate the role of calcitonin gene-related peptide (CGRP) in persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI). Methods: A total of 100 individuals with persistent PTH attributed to mild TBI and 100 age- and gender-matched healthy controls were enrolled between July 2018 and June 2019. Blood was drawn from the antecubital vein and subsequently analyzed using a validated radioimmunoassay for human CGRP. Measurements were performed on coded samples by a board-certified laboratory technician who was blind to clinical information. Results: CGRP plasma levels were lower in subjects with persistent PTH (mean, 75.8 pmol/L; SD, 26.4 pmol/L), compared with age- and gender-matched healthy controls (mean, 88.0 pmol/L; SD, 34.1 pmol/L) (p = 0.04). No correlation was found of CGRP plasma levels with monthly headache days (r = −0.11; p = 0.27), monthly migraine-like days (r = 0.15; p = 0.13), headache quality (r = −0.14; p = 0.15), or a chronic migraine-like headache phenotype (r = −0.02; p = 0.85). Conclusions: CGRP plasma measurements are unlikely a feasible blood-based biomarker of persistent PTH. Future studies should assess whether CGRP plasma measurements can be used to predict development of persistent PTH.
KW - Biomarkers
KW - concussion
KW - head trauma
KW - pathophysiology
U2 - 10.1177/0333102420941115
DO - 10.1177/0333102420941115
M3 - Journal article
C2 - 32689824
AN - SCOPUS:85088306459
VL - 40
SP - 1276
EP - 1282
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 12
ER -
ID: 250540579