Low morbidity in Danish patients with common variable immunodeficiency disorder infected with severe acute respiratory syndrome coronavirus 2
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Low morbidity in Danish patients with common variable immunodeficiency disorder infected with severe acute respiratory syndrome coronavirus 2. / Drabe, Camilla Heldbjerg; Hansen, Ann Brit Eg; Rasmussen, Line Dahlerup; Larsen, Olav Ditlevsen; Møller, Axel; Mogensen, Trine H.; Helweg-Larsen, Jannik; Katzenstein, Terese L.
I: Infectious Diseases, Bind 53, Nr. 12, 2021, s. 953-958.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Low morbidity in Danish patients with common variable immunodeficiency disorder infected with severe acute respiratory syndrome coronavirus 2
AU - Drabe, Camilla Heldbjerg
AU - Hansen, Ann Brit Eg
AU - Rasmussen, Line Dahlerup
AU - Larsen, Olav Ditlevsen
AU - Møller, Axel
AU - Mogensen, Trine H.
AU - Helweg-Larsen, Jannik
AU - Katzenstein, Terese L.
N1 - Funding Information: CD: financial grants for research: Takeda; AEH: financial grants for research and a teaching salary: CSL Behring; THM is funded by a grant from The Novo Nordisk Foundation (NNF21OC0067157); TLK: advisory board member or lecturer for Bristol-Myers Squibb, GlaxoSmithKline/ViiV, Jannsen, Merck Sharp & Dohme, Gilead Sciences, Chiesi, Vertex, CSLBehring, Shire and Takeda; research grant from Gilead Sciences; has participated in immunodeficiency conferences sponsored by CSLBehring, Shire and Takeda. LDR, ODL, AM, JHL: no competing interests. Publisher Copyright: © 2021 Society for Scandinavian Journal of Infectious Diseases.
PY - 2021
Y1 - 2021
N2 - Background: Manifestations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well documented in patients with common variable immunodeficiency disorder (CVID). Methods: A Danish nationwide retrospective clinician-reported survey. Results: Eleven patients with CVID and SARS-CoV-2 infection were identified. The median age was 50 years (range 22–72). All were on immunoglobulin replacement therapy. Eight patients had other pre-existing co-morbidities. Three patients were asymptomatic during the SARS-CoV-2 infection while seven developed mild coronavirus disease 2019 (COVID-19). One patient had more severe disease with hypoxia and required oxygen therapy. This patient had multiple co-morbidities including well known risk factors for severe COVID-19. All patients recovered. Conclusions: The results suggest that CVID may not be a risk factor for severe COVID-19. However, further monitoring of this immunodeficient population is needed to confirm our observation.
AB - Background: Manifestations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well documented in patients with common variable immunodeficiency disorder (CVID). Methods: A Danish nationwide retrospective clinician-reported survey. Results: Eleven patients with CVID and SARS-CoV-2 infection were identified. The median age was 50 years (range 22–72). All were on immunoglobulin replacement therapy. Eight patients had other pre-existing co-morbidities. Three patients were asymptomatic during the SARS-CoV-2 infection while seven developed mild coronavirus disease 2019 (COVID-19). One patient had more severe disease with hypoxia and required oxygen therapy. This patient had multiple co-morbidities including well known risk factors for severe COVID-19. All patients recovered. Conclusions: The results suggest that CVID may not be a risk factor for severe COVID-19. However, further monitoring of this immunodeficient population is needed to confirm our observation.
KW - common variable immunodeficiency
KW - COVID-19
KW - inborn errors of immunity
KW - primary immunodeficiency
KW - SARS-CoV-2
U2 - 10.1080/23744235.2021.1957144
DO - 10.1080/23744235.2021.1957144
M3 - Journal article
C2 - 34375571
AN - SCOPUS:85112236286
VL - 53
SP - 953
EP - 958
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 12
ER -
ID: 302161956