Long-term prognostic significance of homocysteine in middle-aged and elderly
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Long-term prognostic significance of homocysteine in middle-aged and elderly. / Petersen, Julie Falkenberg; Larsen, Bjørn Strøjer; Sabbah, Muhammad; Nielsen, Olav Wendelboe; Kumarathurai, Preman; Sajadieh, Ahmad.
I: Biomarkers, Bind 21, Nr. 6, 2016, s. 490-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long-term prognostic significance of homocysteine in middle-aged and elderly
AU - Petersen, Julie Falkenberg
AU - Larsen, Bjørn Strøjer
AU - Sabbah, Muhammad
AU - Nielsen, Olav Wendelboe
AU - Kumarathurai, Preman
AU - Sajadieh, Ahmad
PY - 2016
Y1 - 2016
N2 - OBJECTIVE: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.RESULTS: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.CONCLUSION: Increased levels of Hcy are associated with all-cause mortality and CV events.
AB - OBJECTIVE: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.RESULTS: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.CONCLUSION: Increased levels of Hcy are associated with all-cause mortality and CV events.
KW - Aged
KW - Biomarkers
KW - Cardiovascular Diseases
KW - Disease-Free Survival
KW - Female
KW - Follow-Up Studies
KW - Homocysteine
KW - Humans
KW - Incidence
KW - Kaplan-Meier Estimate
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Proportional Hazards Models
KW - Risk Factors
KW - Journal Article
U2 - 10.3109/1354750X.2016.1160288
DO - 10.3109/1354750X.2016.1160288
M3 - Journal article
C2 - 27008914
VL - 21
SP - 490
EP - 496
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 6
ER -
ID: 180945775