Longitudinal Increases in Serum Insulin-like Factor 3 and Testosterone Determined by LC-MS/MS in Pubertal Danish Boys
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Longitudinal Increases in Serum Insulin-like Factor 3 and Testosterone Determined by LC-MS/MS in Pubertal Danish Boys. / Albrethsen, Jakob; Ljubicic, Marie Lindhardt; Juul, Anders.
I: Journal of Clinical Endocrinology and Metabolism, Bind 105, Nr. 10, 2020, s. 3173–3178.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Longitudinal Increases in Serum Insulin-like Factor 3 and Testosterone Determined by LC-MS/MS in Pubertal Danish Boys
AU - Albrethsen, Jakob
AU - Ljubicic, Marie Lindhardt
AU - Juul, Anders
N1 - Published by Oxford University Press on behalf of the Endocrine Society 2020.
PY - 2020
Y1 - 2020
N2 - BACKGROUND: Serum concentrations of the peptide hormone insulin-like factor 3 (INSL3) is a candidate marker for improved distinction between constitutional delay of growth and puberty (CDGP) and permanent hypogonadotropic hypogonadism (HH) in boys.AIM: To assess the possible diagnostic role of LC-MS/MS-based INSL3 measurements as a marker of imminent puberty by comparison with testosterone (T) and luteinizing hormone (LH) levels in serum longitudinally collected from 18 healthy boys throughout puberty.RESULTS: The first increase in serum LH was detected on average 4 months earlier, as compared with the first observed increases in INSL3 and T. When comparing the 2 testicular hormones only, we found that in 22% (4 of 18) of the boys the first increase in serum INSL3 was observed prior to the first observed increase in T, whereas in 44% (8 of 18) the first increase in T was observed before the first observed increase in INSL3. In the remaining 6 boys, the 2 testicular hormones showed the first increase at the same examination.CONCLUSION: In some boys with delayed puberty, the first indication of testicular maturation may be detectable by observing serum INSL3. Further studies of LC-MS/MS determination of serum INSL3 in patients with CDGP and HH are warranted.
AB - BACKGROUND: Serum concentrations of the peptide hormone insulin-like factor 3 (INSL3) is a candidate marker for improved distinction between constitutional delay of growth and puberty (CDGP) and permanent hypogonadotropic hypogonadism (HH) in boys.AIM: To assess the possible diagnostic role of LC-MS/MS-based INSL3 measurements as a marker of imminent puberty by comparison with testosterone (T) and luteinizing hormone (LH) levels in serum longitudinally collected from 18 healthy boys throughout puberty.RESULTS: The first increase in serum LH was detected on average 4 months earlier, as compared with the first observed increases in INSL3 and T. When comparing the 2 testicular hormones only, we found that in 22% (4 of 18) of the boys the first increase in serum INSL3 was observed prior to the first observed increase in T, whereas in 44% (8 of 18) the first increase in T was observed before the first observed increase in INSL3. In the remaining 6 boys, the 2 testicular hormones showed the first increase at the same examination.CONCLUSION: In some boys with delayed puberty, the first indication of testicular maturation may be detectable by observing serum INSL3. Further studies of LC-MS/MS determination of serum INSL3 in patients with CDGP and HH are warranted.
KW - Adolescent
KW - Biomarkers/blood
KW - Child
KW - Chromatography, High Pressure Liquid
KW - Denmark
KW - Healthy Volunteers
KW - Humans
KW - Insulin/blood
KW - Longitudinal Studies
KW - Luteinizing Hormone/blood
KW - Male
KW - Pilot Projects
KW - Proteins
KW - Puberty/blood
KW - Reference Values
KW - Tandem Mass Spectrometry
KW - Testosterone/blood
U2 - 10.1210/clinem/dgaa496
DO - 10.1210/clinem/dgaa496
M3 - Journal article
C2 - 32761207
VL - 105
SP - 3173
EP - 3178
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 10
ER -
ID: 259056957