Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output
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Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output. / Dietz, Andrea Grostøl; Weikop, Pia; Hauglund, Natalie; Andersen, Mie; Petersen, Nicolas Caesar; Rose, Laura; Hirase, Hajime; Nedergaard, Maiken.
I: Proceedings of the National Academy of Sciences of the United States of America, Bind 120, Nr. 40, e2305071120, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output
AU - Dietz, Andrea Grostøl
AU - Weikop, Pia
AU - Hauglund, Natalie
AU - Andersen, Mie
AU - Petersen, Nicolas Caesar
AU - Rose, Laura
AU - Hirase, Hajime
AU - Nedergaard, Maiken
N1 - Publisher Copyright: © 2023 the Author(s).
PY - 2023
Y1 - 2023
N2 - Extracellular potassium concentration ([K+]e) is known to increase as a function of arousal. [K+]e is also a potent modulator of transmitter release. Yet, it is not known whether [K+]e is involved in the neuromodulator release associated with behavioral transitions. We here show that manipulating [K+]e controls the local release of monoaminergic neuromodulators, including norepinephrine (NE), serotonin, and dopamine. Imposing a [K+]e increase is adequate to boost local NE levels, and conversely, lowering [K+]e can attenuate local NE. Electroencephalography analysis and behavioral assays revealed that manipulation of cortical [K+]e was sufficient to alter the sleep-wake cycle and behavior of mice. These observations point to the concept that NE levels in the cortex are not solely determined by subcortical release, but that local [K+]e dynamics have a strong impact on cortical NE. Thus, cortical [K+]e is an underappreciated regulator of behavioral transitions.
AB - Extracellular potassium concentration ([K+]e) is known to increase as a function of arousal. [K+]e is also a potent modulator of transmitter release. Yet, it is not known whether [K+]e is involved in the neuromodulator release associated with behavioral transitions. We here show that manipulating [K+]e controls the local release of monoaminergic neuromodulators, including norepinephrine (NE), serotonin, and dopamine. Imposing a [K+]e increase is adequate to boost local NE levels, and conversely, lowering [K+]e can attenuate local NE. Electroencephalography analysis and behavioral assays revealed that manipulation of cortical [K+]e was sufficient to alter the sleep-wake cycle and behavior of mice. These observations point to the concept that NE levels in the cortex are not solely determined by subcortical release, but that local [K+]e dynamics have a strong impact on cortical NE. Thus, cortical [K+]e is an underappreciated regulator of behavioral transitions.
KW - cortical state change
KW - ions
KW - neuromodulators
U2 - 10.1073/pnas.2305071120
DO - 10.1073/pnas.2305071120
M3 - Journal article
C2 - 37774097
AN - SCOPUS:85173766275
VL - 120
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 40
M1 - e2305071120
ER -
ID: 371284941