Left ventricular myocardial crypts: morphological patterns and prognostic implications
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Left ventricular myocardial crypts : morphological patterns and prognostic implications. / Sigvardsen, Per E.; Pham, Michael H.C.; Kühl, Jørgen T.; Fuchs, Andreas; Afzal, Shoaib; Møgelvang, Rasmus; Nordestgaard, Børge G.; Køber, Lars; Kofoed, Klaus F.
I: European Heart Journal Cardiovascular Imaging, Bind 22, Nr. 1, 2021, s. 75-81.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Left ventricular myocardial crypts
T2 - morphological patterns and prognostic implications
AU - Sigvardsen, Per E.
AU - Pham, Michael H.C.
AU - Kühl, Jørgen T.
AU - Fuchs, Andreas
AU - Afzal, Shoaib
AU - Møgelvang, Rasmus
AU - Nordestgaard, Børge G.
AU - Køber, Lars
AU - Kofoed, Klaus F.
PY - 2021
Y1 - 2021
N2 - AIMS : Left ventricular (LV) myocardial crypts are considered a subtle marker of hypertrophic cardiomyopathy. However, crypts have also been observed in seemingly healthy individuals and it is unknown whether myocardial crypts are associated with adverse outcome. METHODS AND RESULTS : Myocardial crypts were defined as invaginations traversing >50% of the myocardial wall and assessed using contrast-enhanced cardiac computed tomography in 10 097 individuals from the Copenhagen General Population Study. Number of crypts, location, shape, penetrance, and volume were assessed. The endpoint was a composite of major adverse cardiovascular events and defined as death, myocardial infarction, heart failure, or stroke. Cox regression models were adjusted for clinical variables, medical history, electrocardiographic parameters, and cardiac chamber sizes. A total of 1199 LV myocardial crypts were identified in 915 (9.1%) individuals. Seven hundred (6.9%) had one crypt and 215 (2.1%) had multiple crypts. During a median follow-up of 4.0 years (interquartile range 1.5-6.7), major adverse cardiovascular events occurred in 619 individuals. Individuals with one or multiple crypts had a hazard ratio for major adverse cardiovascular events of 1.00 [95% confidence interval (CI): 0.72-1.40; P = 0.98] and 0.90 (95% CI: 0.47-1.75; P = 0.76), respectively, compared with those with no crypts. No specific pattern of crypt location, shape, penetrance, or volume was associated to an increased hazard ratio for major adverse cardiovascular events. CONCLUSION : LV myocardial crypts are frequent in the general population and are not associated with intermediate-term major adverse cardiovascular events.
AB - AIMS : Left ventricular (LV) myocardial crypts are considered a subtle marker of hypertrophic cardiomyopathy. However, crypts have also been observed in seemingly healthy individuals and it is unknown whether myocardial crypts are associated with adverse outcome. METHODS AND RESULTS : Myocardial crypts were defined as invaginations traversing >50% of the myocardial wall and assessed using contrast-enhanced cardiac computed tomography in 10 097 individuals from the Copenhagen General Population Study. Number of crypts, location, shape, penetrance, and volume were assessed. The endpoint was a composite of major adverse cardiovascular events and defined as death, myocardial infarction, heart failure, or stroke. Cox regression models were adjusted for clinical variables, medical history, electrocardiographic parameters, and cardiac chamber sizes. A total of 1199 LV myocardial crypts were identified in 915 (9.1%) individuals. Seven hundred (6.9%) had one crypt and 215 (2.1%) had multiple crypts. During a median follow-up of 4.0 years (interquartile range 1.5-6.7), major adverse cardiovascular events occurred in 619 individuals. Individuals with one or multiple crypts had a hazard ratio for major adverse cardiovascular events of 1.00 [95% confidence interval (CI): 0.72-1.40; P = 0.98] and 0.90 (95% CI: 0.47-1.75; P = 0.76), respectively, compared with those with no crypts. No specific pattern of crypt location, shape, penetrance, or volume was associated to an increased hazard ratio for major adverse cardiovascular events. CONCLUSION : LV myocardial crypts are frequent in the general population and are not associated with intermediate-term major adverse cardiovascular events.
KW - hypertrophic cardiomyopathy
KW - left ventricular myocardial crypts
KW - myocardial disease
U2 - 10.1093/ehjci/jeaa020
DO - 10.1093/ehjci/jeaa020
M3 - Journal article
C2 - 32083645
AN - SCOPUS:85090089228
VL - 22
SP - 75
EP - 81
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
SN - 2047-2404
IS - 1
ER -
ID: 255354335