Knoglemarvstransplantation og chimeric antigen receptor-T-celleterapi
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Knoglemarvstransplantation og chimeric antigen receptor-T-celleterapi. / Sengeløv, Henrik; Petersen, Søren Lykke.
I: Ugeskrift for Laeger, Bind 183, Nr. 42, V03210280, 18.10.2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Knoglemarvstransplantation og chimeric antigen receptor-T-celleterapi
AU - Sengeløv, Henrik
AU - Petersen, Søren Lykke
PY - 2021/10/18
Y1 - 2021/10/18
N2 - Malignant hematologic diseases resistant to chemotherapy can be cured by immune cellular therapy. Bone marrow transplantation (BMT) elicits a "pan-immunologic" attack, whereas therapy with chimeric antigen receptor (CAR)-T is a targeted attack. The immunologic activity after BMT can be adjusted by selection of donor cells before transplantation, or with post-BMT sequential chemotherapy. Many haematologic diseases are clonal, and the development of CAR-T cellular therapy directed against a variety of epitopes is under development as summarised in this review.
AB - Malignant hematologic diseases resistant to chemotherapy can be cured by immune cellular therapy. Bone marrow transplantation (BMT) elicits a "pan-immunologic" attack, whereas therapy with chimeric antigen receptor (CAR)-T is a targeted attack. The immunologic activity after BMT can be adjusted by selection of donor cells before transplantation, or with post-BMT sequential chemotherapy. Many haematologic diseases are clonal, and the development of CAR-T cellular therapy directed against a variety of epitopes is under development as summarised in this review.
KW - Bone Marrow Transplantation
KW - Humans
KW - Tissue Donors
M3 - Tidsskriftartikel
C2 - 34709159
VL - 183
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 42
M1 - V03210280
ER -
ID: 305690506