Kinetics and dose calculations of ampicillin and gentamicin given as continuous intravenous infusion during parenteral nutrition in 88 newborn infants.
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Kinetics and dose calculations of ampicillin and gentamicin given as continuous intravenous infusion during parenteral nutrition in 88 newborn infants. / Colding, H; Møller, S; Bentzon, M W.
I: Developmental Pharmacology and Therapeutics, Bind 6, Nr. 6, 1983, s. 365-73.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Kinetics and dose calculations of ampicillin and gentamicin given as continuous intravenous infusion during parenteral nutrition in 88 newborn infants.
AU - Colding, H
AU - Møller, S
AU - Bentzon, M W
N1 - Keywords: Ampicillin; Female; Gentamicins; Half-Life; Humans; Infant, Newborn; Infusions, Parenteral; Kinetics; Male; Parenteral Nutrition
PY - 1983
Y1 - 1983
N2 - Ampicillin and gentamicin were administered continuously intravenously to 88 newborn infants using individually calculated dosages. For infants with a mean value of plasma clearance of the antibiotics, it was calculated that the serum ampicillin and gentamicin concentrations would be between 35-55 and 3-5 micrograms/ml, respectively, using the dosages for intermittent treatment. These dosages are therefore recommended as fixed dosages for continuous intravenous infusion initiated by a bolus dosage. Serum gentamicin concentration should be assayed about three half-lives after start of infusion and the dosage adjusted for values outside 3-5 micrograms/ml.
AB - Ampicillin and gentamicin were administered continuously intravenously to 88 newborn infants using individually calculated dosages. For infants with a mean value of plasma clearance of the antibiotics, it was calculated that the serum ampicillin and gentamicin concentrations would be between 35-55 and 3-5 micrograms/ml, respectively, using the dosages for intermittent treatment. These dosages are therefore recommended as fixed dosages for continuous intravenous infusion initiated by a bolus dosage. Serum gentamicin concentration should be assayed about three half-lives after start of infusion and the dosage adjusted for values outside 3-5 micrograms/ml.
M3 - Journal article
C2 - 6416802
VL - 6
SP - 365
EP - 373
JO - Developmental Pharmacology and Therapeutics
JF - Developmental Pharmacology and Therapeutics
SN - 0379-8305
IS - 6
ER -
ID: 8670182