Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees
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Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees. / Thielen, Karsten; Nygaard, Else; Rugulies, Reiner; Diderichsen, Finn.
I: Journal of Occupational and Environmental Medicine, Bind 68, Nr. 3, 2011, s. 205-10.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees
AU - Thielen, Karsten
AU - Nygaard, Else
AU - Rugulies, Reiner
AU - Diderichsen, Finn
PY - 2011
Y1 - 2011
N2 - ABSTRACTObjectives To investigate if exposure to adversepsychological job characteristics predicts incident use ofantidepressants, taking into account differentialmisclassification and residual confounding.Methods A prospective cohort study with a 3.5-yearfollow-up of 4661 Danish employees, aged 40 and50 years, drawn from a 10% random sample of theDanish population was carried out. Job characteristicswere the predictor variables and use of antidepressantswas the outcome variable. Survey data on psychosocialwork environment were linked with register data ondispensing of antidepressant medicine between June2000 and December 2003. Respondents with majordepression at baseline, with antidepressant use in the5 years preceding baseline, or not employed at baselinewere excluded.Results Among men, the OR for antidepressant use wassignificantly increased for high quantitative demands (OR2.12, 95% CI 1.29 to 3.48) and low social support fromcolleagues (OR 2.28, 95% 1.36 to 3.82) after adjustmentfor lifestyle factors, socio-demographic factors,co-morbidity, other work factors and depressivesymptoms at baseline. Both effects were dosedependent. An interaction effect with high demands wasfound for high anticipated private social support andliving with children. Among women, no effect of jobcharacteristics on antidepressant use was found.Conclusion Among men, but not among women, highquantitative demands and low social support fromcolleagues were predictive of incident use ofantidepressants, indicating incident depressive episodes,even after taking into account differentialmisclassification and residual confounding. The effectswere buffered for those with high anticipated privatesocial support and for those having children.
AB - ABSTRACTObjectives To investigate if exposure to adversepsychological job characteristics predicts incident use ofantidepressants, taking into account differentialmisclassification and residual confounding.Methods A prospective cohort study with a 3.5-yearfollow-up of 4661 Danish employees, aged 40 and50 years, drawn from a 10% random sample of theDanish population was carried out. Job characteristicswere the predictor variables and use of antidepressantswas the outcome variable. Survey data on psychosocialwork environment were linked with register data ondispensing of antidepressant medicine between June2000 and December 2003. Respondents with majordepression at baseline, with antidepressant use in the5 years preceding baseline, or not employed at baselinewere excluded.Results Among men, the OR for antidepressant use wassignificantly increased for high quantitative demands (OR2.12, 95% CI 1.29 to 3.48) and low social support fromcolleagues (OR 2.28, 95% 1.36 to 3.82) after adjustmentfor lifestyle factors, socio-demographic factors,co-morbidity, other work factors and depressivesymptoms at baseline. Both effects were dosedependent. An interaction effect with high demands wasfound for high anticipated private social support andliving with children. Among women, no effect of jobcharacteristics on antidepressant use was found.Conclusion Among men, but not among women, highquantitative demands and low social support fromcolleagues were predictive of incident use ofantidepressants, indicating incident depressive episodes,even after taking into account differentialmisclassification and residual confounding. The effectswere buffered for those with high anticipated privatesocial support and for those having children.
KW - Adult
KW - Antidepressive Agents
KW - Confounding Factors (Epidemiology)
KW - Denmark
KW - Depression
KW - Drug Utilization
KW - Epidemiologic Methods
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Occupational Diseases
KW - Social Support
KW - Stress, Psychological
KW - Depression
KW - Arbejdsmiljø
U2 - 10.1136/oem.2010.057943
DO - 10.1136/oem.2010.057943
M3 - Journal article
C2 - 20935295
VL - 68
SP - 205
EP - 210
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
SN - 1076-2752
IS - 3
ER -
ID: 33714285