TY - JOUR

T1 - Is suppressed thyroid-stimulating hormone (TSH) associated with subclinical depression in the Danish General Suburban Population Study?

AU - Kvetny, Jan

AU - Ellervik, Christina

AU - Bech, Per

PY - 2015/5

Y1 - 2015/5

N2 - BACKGROUND: The first phase of the Danish General Suburban Population Study (GESUS) including 8214 individuals was an attempt to evaluate the association between subclinical hypothyroidism without or with elevated peroxidase antibodies and depression. No such association was found. In the second phase, including 14,787 individuals, we have focused on suppressed TSH (thyroid-stimulating hormone) and depression.AIMS: To evaluate to what extent suppressed TSH is associated with subclinical depression.METHODS: The total scores of the Major Depression Inventory (MDI) were used to evaluate subclinical depression, both by its total score and by an algorithm of the subthreshold depressed by presence of at least three of the 10 ICD-10 depression symptoms. Serum levels of TSH were used to classify the individuals into suppressed (TSH < 0.4 mIU/l), elevated (TSH ≥ 3.8 mIU/l) and normal reference (TSH between 0.4 and 3.7 mIU/l).RESULTS: We identified 285 individuals with suppressed TSH and 1266 individuals with elevated TSH. The MDI total score was 7.55 in suppressed TSH individuals, 6.22 in elevated TSH individuals and 6.52 in normal reference individuals (P = 0.01). When the MDI was used diagnostically to identify subclinical depression, the prevalence was 8.07% in suppressed TSH individuals, 5.8% in normal reference individuals and 5.29% in elevated TSH individuals.CONCLUSION: This population-based study supports that persons with suppressed TSH (subclinical hyperthyroidism) seem to have a risk, although small, of subclinical depression.

AB - BACKGROUND: The first phase of the Danish General Suburban Population Study (GESUS) including 8214 individuals was an attempt to evaluate the association between subclinical hypothyroidism without or with elevated peroxidase antibodies and depression. No such association was found. In the second phase, including 14,787 individuals, we have focused on suppressed TSH (thyroid-stimulating hormone) and depression.AIMS: To evaluate to what extent suppressed TSH is associated with subclinical depression.METHODS: The total scores of the Major Depression Inventory (MDI) were used to evaluate subclinical depression, both by its total score and by an algorithm of the subthreshold depressed by presence of at least three of the 10 ICD-10 depression symptoms. Serum levels of TSH were used to classify the individuals into suppressed (TSH < 0.4 mIU/l), elevated (TSH ≥ 3.8 mIU/l) and normal reference (TSH between 0.4 and 3.7 mIU/l).RESULTS: We identified 285 individuals with suppressed TSH and 1266 individuals with elevated TSH. The MDI total score was 7.55 in suppressed TSH individuals, 6.22 in elevated TSH individuals and 6.52 in normal reference individuals (P = 0.01). When the MDI was used diagnostically to identify subclinical depression, the prevalence was 8.07% in suppressed TSH individuals, 5.8% in normal reference individuals and 5.29% in elevated TSH individuals.CONCLUSION: This population-based study supports that persons with suppressed TSH (subclinical hyperthyroidism) seem to have a risk, although small, of subclinical depression.

KW - Adult

KW - Aged

KW - Biomarkers

KW - Cross-Sectional Studies

KW - Denmark

KW - Depressive Disorder, Major

KW - Female

KW - Humans

KW - Hypothyroidism

KW - Male

KW - Middle Aged

KW - Suburban Population

KW - Thyrotropin

U2 - 10.3109/08039488.2014.972454

DO - 10.3109/08039488.2014.972454

M3 - Journal article

C2 - 25377023

VL - 69

SP - 282

EP - 286

JO - Nordisk Psykiatrisk Tidsskrift

JF - Nordisk Psykiatrisk Tidsskrift

SN - 0803-9496

IS - 4

ER -