Ion-driven rotary membrane motors: From structure to function
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Ion-driven membrane motors, essential across all domains of life, convert a gradient of ions across a membrane into rotational energy, facilitating diverse biological processes including ATP synthesis, substrate transport, and bacterial locomotion. Herein, we highlight recent structural advances in the understanding of two classes of ion-driven membrane motors: rotary ATPases and 5:2 motors. The recent structure of the human F-type ATP synthase is emphasised along with the gained structural insight into clinically relevant mutations. Furthermore, we highlight the diverse roles of 5:2 motors and recent mechanistic understanding gained through the resolution of ions in the structure of a sodium-driven motor, combining insights into potential unifying mechanisms of ion selectivity and rotational torque generation in the context of their function as part of complex biological systems.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 102884 |
| Tidsskrift | Current Opinion in Structural Biology |
| Vol/bind | 88 |
| Antal sider | 10 |
| ISSN | 0959-440X |
| DOI | |
| Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
We would like to thank all members of the Protein Structure & Function Program for their support and useful discussions throughout the work of this project and the surrounding projects. The Novo Nordisk Foundation Center for Protein Research is supported financially by the Novo Nordisk Foundation (NNF14CC0001). N.M.I.T. acknowledges support from a Novo Nordisk Foundation Hallas M\u00F8ller Emerging Investigator grant (NNF17OC0031006), a Novo Nordisk Foundation Hallas-M\u00F8ller Ascending Investigator grant (NNF23OC0081528) and a Novo Nordisk Foundation Project grant (NNF21OC0071948). H.H. acknowledges support from Lundbeck Foundation postdoc fellowship R347-2020-2429.
Funding Information:
We would like to thank all members of the Protein Structure & Function Program for their support and useful discussions throughout the work of this project and the surrounding projects. The Novo Nordisk Foundation Center for Protein Research is supported financially by the Novo Nordisk Foundation (NNF14CC0001). N.M.I.T. acknowledges support from a Novo Nordisk Foundation Hallas M\u00F8ller Emerging Investigator grant (NNF17OC0031006). H.H. acknowledges support from Lundbeck Foundation postdoc fellowship R347-2020-2429. We would also like to thank Alistair Scott for the inspiration for the title.
Publisher Copyright:
© 2024 The Author(s)
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