Involvement of adenosine signaling pathway in migraine pathophysiology: a systematic review of preclinical studies
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Involvement of adenosine signaling pathway in migraine pathophysiology : a systematic review of preclinical studies. / Thuraiaiyah, Janu; Kokoti, Lili; Al-Karagholi, Mohammad Al-Mahdi; Ashina, Messoud.
I: Journal of Headache and Pain, Bind 23, 43, 2022.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Involvement of adenosine signaling pathway in migraine pathophysiology
T2 - a systematic review of preclinical studies
AU - Thuraiaiyah, Janu
AU - Kokoti, Lili
AU - Al-Karagholi, Mohammad Al-Mahdi
AU - Ashina, Messoud
PY - 2022
Y1 - 2022
N2 - Background Adenosine is a purinergic signaling molecule with a wide range of physiological functions including anti- and pronociceptive properties. Adenosine receptors are expressed in the trigeminovascular system, and adenosine receptor antagonist, caffeine, relieves migraine headache. We performed a systematic review of the literature of preclinical data addressing the role of adenosine in migraine pathophysiology. Methods PubMed and EMBASE were searched for pre-clinical studies on the role of adenosine in migraine pathophysiology on September 5(th), 2021. Results A total of 2510 studies were screened by title and abstract. Of these, thirteen pre-clinical studies evaluating adenosine, adenosine A1, A2A and A3 receptors were included. These studies showed that adenosine signaling pathway is involved in controlling vascular tone. Furthermore, electrical stimulation of the trigeminal ganglion modulates the expression of adenosine A(1) and A(2A) receptors in the trigeminal ganglion and trigeminal nucleus caudalis implicating adenosine signaling pathway in pain transmission. Conclusion Preclinical studies showed that adenosine has a dual effect on vasodilation and trigeminal pain pathway due to different receptor activation, suggesting a possible role of adenosine in migraine pathophysiology. Studies investigating pharmacological characteristics of subtypes of adenosine receptors are needed to further elucidate their role as a potential target for migraine treatment.
AB - Background Adenosine is a purinergic signaling molecule with a wide range of physiological functions including anti- and pronociceptive properties. Adenosine receptors are expressed in the trigeminovascular system, and adenosine receptor antagonist, caffeine, relieves migraine headache. We performed a systematic review of the literature of preclinical data addressing the role of adenosine in migraine pathophysiology. Methods PubMed and EMBASE were searched for pre-clinical studies on the role of adenosine in migraine pathophysiology on September 5(th), 2021. Results A total of 2510 studies were screened by title and abstract. Of these, thirteen pre-clinical studies evaluating adenosine, adenosine A1, A2A and A3 receptors were included. These studies showed that adenosine signaling pathway is involved in controlling vascular tone. Furthermore, electrical stimulation of the trigeminal ganglion modulates the expression of adenosine A(1) and A(2A) receptors in the trigeminal ganglion and trigeminal nucleus caudalis implicating adenosine signaling pathway in pain transmission. Conclusion Preclinical studies showed that adenosine has a dual effect on vasodilation and trigeminal pain pathway due to different receptor activation, suggesting a possible role of adenosine in migraine pathophysiology. Studies investigating pharmacological characteristics of subtypes of adenosine receptors are needed to further elucidate their role as a potential target for migraine treatment.
KW - Headache
KW - Adenosine receptor
KW - Pre-clinical
KW - Pain
KW - RECEPTOR AGONIST GR79236
KW - SENSITIVE K+ CHANNELS
KW - ADENOSINE-A1-RECEPTOR AGONIST
KW - PEPTIDE RELEASE
KW - ANTAGONIST
KW - PHARMACOLOGY
KW - STIMULATION
U2 - 10.1186/s10194-022-01412-0
DO - 10.1186/s10194-022-01412-0
M3 - Review
C2 - 35382738
VL - 23
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
SN - 1129-2369
M1 - 43
ER -
ID: 344810916