Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis
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Investigation of the genetic association between quantitative measures of psychosis and schizophrenia : a polygenic risk score analysis. / Derks, Eske M; Vorstman, Jacob A S; Ripke, Stephan; Kahn, Rene S; Ophoff, Roel A; Schizophrenia Psychiatric Genomic Consortium; Hansen, Thomas; Olsen, Line; Jakobsen, Klaus Damgaard; Schmock, Henriette; Skjødt, Celina; Rosengren, Anders; Høffding, Louise.K.Enggaard; Thygesen, Johan Hilge; Werge, Thomas Mears.
I: P L o S One, Bind 7, Nr. 6, 2012, s. e37852.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Investigation of the genetic association between quantitative measures of psychosis and schizophrenia
T2 - a polygenic risk score analysis
AU - Derks, Eske M
AU - Vorstman, Jacob A S
AU - Ripke, Stephan
AU - Kahn, Rene S
AU - Ophoff, Roel A
AU - Schizophrenia Psychiatric Genomic Consortium
AU - Hansen, Thomas
AU - Olsen, Line
AU - Jakobsen, Klaus Damgaard
AU - Schmock, Henriette
AU - Skjødt, Celina
AU - Rosengren, Anders
AU - Høffding, Louise.K.Enggaard
AU - Thygesen, Johan Hilge
AU - Werge, Thomas Mears
PY - 2012
Y1 - 2012
N2 - The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p
AB - The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p
U2 - 10.1371/journal.pone.0037852
DO - 10.1371/journal.pone.0037852
M3 - Journal article
C2 - 22761660
VL - 7
SP - e37852
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 6
ER -
ID: 48609884