TY - JOUR

T1 - Investigation of the genetic association between quantitative measures of psychosis and schizophrenia

T2 - a polygenic risk score analysis

AU - Derks, Eske M

AU - Vorstman, Jacob A S

AU - Ripke, Stephan

AU - Kahn, Rene S

AU - Ophoff, Roel A

AU - Schizophrenia Psychiatric Genomic Consortium

AU - Hansen, Thomas

AU - Olsen, Line

AU - Jakobsen, Klaus Damgaard

AU - Schmock, Henriette

AU - Skjødt, Celina

AU - Rosengren, Anders

AU - Høffding, Louise.K.Enggaard

AU - Thygesen, Johan Hilge

AU - Werge, Thomas Mears

PY - 2012

Y1 - 2012

N2 - The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p

AB - The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p

U2 - 10.1371/journal.pone.0037852

DO - 10.1371/journal.pone.0037852

M3 - Journal article

C2 - 22761660

VL - 7

SP - e37852

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 6

ER -