Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects

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Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. / Magkos, Faidon; Su, Xiong; Bradley, David; Fabbrini, Elisa; Conte, Caterina; Eagon, J Christopher; Varela, J Esteban; Brunt, Elizabeth M; Patterson, Bruce W; Klein, Samuel.

I: Gastroenterology, Bind 142, Nr. 7, 2012, s. 1444-1446.e2.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Magkos, F, Su, X, Bradley, D, Fabbrini, E, Conte, C, Eagon, JC, Varela, JE, Brunt, EM, Patterson, BW & Klein, S 2012, 'Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects', Gastroenterology, bind 142, nr. 7, s. 1444-1446.e2. https://doi.org/10.1053/j.gastro.2012.03.003

APA

Magkos, F., Su, X., Bradley, D., Fabbrini, E., Conte, C., Eagon, J. C., Varela, J. E., Brunt, E. M., Patterson, B. W., & Klein, S. (2012). Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology, 142(7), 1444-1446.e2. https://doi.org/10.1053/j.gastro.2012.03.003

Vancouver

Magkos F, Su X, Bradley D, Fabbrini E, Conte C, Eagon JC o.a. Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology. 2012;142(7):1444-1446.e2. https://doi.org/10.1053/j.gastro.2012.03.003

Author

Magkos, Faidon ; Su, Xiong ; Bradley, David ; Fabbrini, Elisa ; Conte, Caterina ; Eagon, J Christopher ; Varela, J Esteban ; Brunt, Elizabeth M ; Patterson, Bruce W ; Klein, Samuel. / Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. I: Gastroenterology. 2012 ; Bind 142, Nr. 7. s. 1444-1446.e2.

Bibtex

@article{baf3abc5af6243ab90332c0d1b3a2c2b,

title = "Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects",

abstract = "Data from studies in animal models indicate that certain lipid metabolites, particularly diacylglycerol, ceramide, and acylcarnitine, disrupt insulin action. We evaluated the relationship between the presence of these metabolites in the liver (assessed by mass spectrometry) and hepatic insulin sensitivity (assessed using a hyperinsulinemic-euglycemic clamp with stable isotope tracer infusion) in 16 obese adults (body mass index, 48 ± 9 kg/m²). There was a negative correlation between insulin-mediated suppression of hepatic glucose production and intrahepatic diacylglycerol (r = -0.609; P = .012), but not with intrahepatic ceramide or acylcarnitine. These data indicate that intrahepatic diacylglycerol is an important mediator of hepatic insulin resistance in obese people with nonalcoholic fatty liver disease.",

keywords = "Adult, Carnitine/analogs & derivatives, Ceramides/metabolism, Diglycerides/metabolism, Female, Glucose/metabolism, Humans, Insulin Resistance, Liver/metabolism, Male, Obesity, Morbid/metabolism",

author = "Faidon Magkos and Xiong Su and David Bradley and Elisa Fabbrini and Caterina Conte and Eagon, {J Christopher} and Varela, {J Esteban} and Brunt, {Elizabeth M} and Patterson, {Bruce W} and Samuel Klein",

year = "2012",

doi = "10.1053/j.gastro.2012.03.003",

language = "English",

volume = "142",

pages = "1444--1446.e2",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "Elsevier",

number = "7",

}

RIS

TY - JOUR

T1 - Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects

AU - Magkos, Faidon

AU - Su, Xiong

AU - Bradley, David

AU - Fabbrini, Elisa

AU - Conte, Caterina

AU - Eagon, J Christopher

AU - Varela, J Esteban

AU - Brunt, Elizabeth M

AU - Patterson, Bruce W

AU - Klein, Samuel

PY - 2012

Y1 - 2012

N2 - Data from studies in animal models indicate that certain lipid metabolites, particularly diacylglycerol, ceramide, and acylcarnitine, disrupt insulin action. We evaluated the relationship between the presence of these metabolites in the liver (assessed by mass spectrometry) and hepatic insulin sensitivity (assessed using a hyperinsulinemic-euglycemic clamp with stable isotope tracer infusion) in 16 obese adults (body mass index, 48 ± 9 kg/m²). There was a negative correlation between insulin-mediated suppression of hepatic glucose production and intrahepatic diacylglycerol (r = -0.609; P = .012), but not with intrahepatic ceramide or acylcarnitine. These data indicate that intrahepatic diacylglycerol is an important mediator of hepatic insulin resistance in obese people with nonalcoholic fatty liver disease.

AB - Data from studies in animal models indicate that certain lipid metabolites, particularly diacylglycerol, ceramide, and acylcarnitine, disrupt insulin action. We evaluated the relationship between the presence of these metabolites in the liver (assessed by mass spectrometry) and hepatic insulin sensitivity (assessed using a hyperinsulinemic-euglycemic clamp with stable isotope tracer infusion) in 16 obese adults (body mass index, 48 ± 9 kg/m²). There was a negative correlation between insulin-mediated suppression of hepatic glucose production and intrahepatic diacylglycerol (r = -0.609; P = .012), but not with intrahepatic ceramide or acylcarnitine. These data indicate that intrahepatic diacylglycerol is an important mediator of hepatic insulin resistance in obese people with nonalcoholic fatty liver disease.

KW - Adult

KW - Carnitine/analogs & derivatives

KW - Ceramides/metabolism

KW - Diglycerides/metabolism

KW - Female

KW - Glucose/metabolism

KW - Humans

KW - Insulin Resistance

KW - Liver/metabolism

KW - Male

KW - Obesity, Morbid/metabolism

U2 - 10.1053/j.gastro.2012.03.003

DO - 10.1053/j.gastro.2012.03.003

M3 - Journal article

C2 - 22425588

VL - 142

SP - 1444-1446.e2

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 7

ER -

ID: 290034221