TY - JOUR

T1 - International veterinary epilepsy task force consensus proposal

T2 - outcome of therapeutic interventions in canine and feline epilepsy

AU - Potschka, Heidrun

AU - Fischer, Andrea

AU - Löscher, Wolfgang

AU - Patterson, Ned

AU - Bhatti, Sofie

AU - Berendt, Mette

AU - De Risio, Luisa

AU - Farquhar, Robyn

AU - Long, Sam

AU - Mandigers, Paul

AU - Matiasek, Kaspar

AU - Muñana, Karen

AU - Pakozdy, Akos

AU - Penderis, Jacques

AU - Platt, Simon

AU - Podell, Michael

AU - Rusbridge, Clare

AU - Stein, Veronika

AU - Tipold, Andrea

AU - Volk, Holger A

PY - 2015

Y1 - 2015

N2 - Common criteria for the diagnosis of drug resistance and the assessment of outcome are needed urgently as a prerequisite for standardized evaluation and reporting of individual therapeutic responses in canine epilepsy. Thus, we provide a proposal for the definition of drug resistance and partial therapeutic success in canine patients with epilepsy. This consensus statement also suggests a list of factors and aspects of outcome, which should be considered in addition to the impact on seizures. Moreover, these expert recommendations discuss criteria which determine the validity and informative value of a therapeutic trial in an individual patient and also suggest the application of individual outcome criteria. Agreement on common guidelines does not only render a basis for future optimization of individual patient management, but is also a presupposition for the design and implementation of clinical studies with highly standardized inclusion and exclusion criteria. Respective standardization will improve the comparability of findings from different studies and renders an improved basis for multicenter studies. Therefore, this proposal provides an in-depth discussion of the implications of outcome criteria for clinical studies. In particular ethical aspects and the different options for study design and application of individual patient-centered outcome criteria are considered.

AB - Common criteria for the diagnosis of drug resistance and the assessment of outcome are needed urgently as a prerequisite for standardized evaluation and reporting of individual therapeutic responses in canine epilepsy. Thus, we provide a proposal for the definition of drug resistance and partial therapeutic success in canine patients with epilepsy. This consensus statement also suggests a list of factors and aspects of outcome, which should be considered in addition to the impact on seizures. Moreover, these expert recommendations discuss criteria which determine the validity and informative value of a therapeutic trial in an individual patient and also suggest the application of individual outcome criteria. Agreement on common guidelines does not only render a basis for future optimization of individual patient management, but is also a presupposition for the design and implementation of clinical studies with highly standardized inclusion and exclusion criteria. Respective standardization will improve the comparability of findings from different studies and renders an improved basis for multicenter studies. Therefore, this proposal provides an in-depth discussion of the implications of outcome criteria for clinical studies. In particular ethical aspects and the different options for study design and application of individual patient-centered outcome criteria are considered.

U2 - 10.1186/s12917-015-0465-y

DO - 10.1186/s12917-015-0465-y

M3 - Journal article

C2 - 26314300

VL - 11

JO - B M C Veterinary Research

JF - B M C Veterinary Research

SN - 1746-6148

M1 - 177

ER -